Surface modification of polyurethane via creating a biocompatible superhydrophilic nanostructured layer: role of surface chemistry and structure

Fatemeh Noorisafa, Amir Razmjou, Nahid Emami, Ze Xian Low, Asghar Habibnejad Korayem, Abolghasem Abbasi Kajani

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13 Citations (Scopus)

Abstract

Advanced surface modification approaches of biomaterials alongside the advent of sophisticated analytical techniques have provided a great opportunity to understand how the physicochemical characteristics of materials determine cell–surface dynamics at molecular and atomic scale. However, there are still many contradictory reports, which are mainly due to inadequate information about the role of the two parameters of surface chemistry and structure and their synergistic effect as an adequate predictor of biological performance. Here, surface parameters were altered by grafting of poly ethylene glycol (PEG) on polyurethane (PU) surfaces through a superhydrophilic modification method. In this study, surface modification of PU films by PEG thin layer via grafting technique and TiO2 nanoparticle entrapment in the brush polymers was investigated. The surface modification led to a reduction in protein adsorption and bacterial attachment by 8.7 times and 71% respectively with no cytotoxicity effect on HeLa cells. It was also observed that when PU surface became superhydrophilic the bacterial adhesion becomes independent of bacterium type. In general, it was observed that the impact of topographical changes on the biocompatibility and biofilm formation becomes significantly more profound than that of the surface chemistry alteration.

Original languageEnglish
Pages (from-to)1087-1109
Number of pages23
JournalJournal of Experimental Nanoscience
Volume11
Issue number14
DOIs
Publication statusPublished - 21 Sep 2016
Externally publishedYes

Keywords

  • bacterial attachment
  • nanostructured surfaces
  • protein adsorption
  • superhydrophilicity
  • TiO/PEG

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