Abstract
We report a templating approach for the preparation of functional polymer replica particles via surface-initiated polymerization in mesoporous silica templates. Subsequent removal of the template resulted in discrete polymer particles. Furthermore, redox-responsive replica particles could be engineered to disassemble in a reducing environment. Particles, made of poly(methacryloyloxyethyl phosphorylcholine) (PMPC) or poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), exhibited very low association to human cancer cells (below 5%), which renders the reported charge-neutral polymer particles a modular and versatile class of highly functional carriers with potential applications in drug delivery.
Original language | English |
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Pages (from-to) | 6286-6293 |
Number of pages | 8 |
Journal | Langmuir |
Volume | 30 |
Issue number | 21 |
DOIs | |
Publication status | Published - 3 Jun 2014 |
Externally published | Yes |