Surface engineering to improve the flowability and fluidization of a cohesive powder

David Alexander Vodden Morton, Qi Zhou, B Armstrong, Ian Clair Larson, Peter James Stewart

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Fine pharmaceutical powder formulations must exhibit satisfactory powder flow during production, transportation and administration. We have shown that mechanical co-processing of fine powders with small quantities of magnesium stearate can radically change the behaviour of fine lactose powders. We report investigations of the basic characteristics of such powders, which have undergone mechanofusion with surface modifying additives, and compare these to unmodified powders, and powders subjected to conventional blending. The study looked at both flow characteristics, as well as fluidization behaviours of a model powder, with median diameter of 8A?m. A powder rheometer was used to probe flow and cohesion properties and these analyses are used to improve understanding of formulation performance. This work indicated that a substantial improvement in flow and fluidization behaviours could be achieved for fine lactose powders within the specific size range by appropriate surface modification. In addition, we observed behaviour changes that appear to derive from changes in packing density and inter-particulate cohesion. The observations have significant implications for future formulation optimisation, and support a Quality by Design formulation approach to product development risk management.
Original languageEnglish
Title of host publicationCHEMECA 2009
EditorsT Heyns, M Ang, C Butler, P Hay, R Kelson, J Langford, Y K Leong, P McEwen, D Montgomery, P Snowsill, M Tade
Place of PublicationAustralia
PublisherEngineers Australia
PagesCD - CD
Number of pages9
ISBN (Print)9780858259225
Publication statusPublished - 2009
EventChemeca: Australasian Conference on Chemical Engineering 2009 - Perth, W.A., Perth, Australia
Duration: 1 Jan 2009 → …

Conference

ConferenceChemeca: Australasian Conference on Chemical Engineering 2009
CountryAustralia
CityPerth
Period1/01/09 → …

Cite this

Morton, D. A. V., Zhou, Q., Armstrong, B., Larson, I. C., & Stewart, P. J. (2009). Surface engineering to improve the flowability and fluidization of a cohesive powder. In T. Heyns, M. Ang, C. Butler, P. Hay, R. Kelson, J. Langford, Y. K. Leong, P. McEwen, D. Montgomery, P. Snowsill, ... M. Tade (Eds.), CHEMECA 2009 (pp. CD - CD). Australia: Engineers Australia.
Morton, David Alexander Vodden ; Zhou, Qi ; Armstrong, B ; Larson, Ian Clair ; Stewart, Peter James. / Surface engineering to improve the flowability and fluidization of a cohesive powder. CHEMECA 2009. editor / T Heyns ; M Ang ; C Butler ; P Hay ; R Kelson ; J Langford ; Y K Leong ; P McEwen ; D Montgomery ; P Snowsill ; M Tade. Australia : Engineers Australia, 2009. pp. CD - CD
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title = "Surface engineering to improve the flowability and fluidization of a cohesive powder",
abstract = "Fine pharmaceutical powder formulations must exhibit satisfactory powder flow during production, transportation and administration. We have shown that mechanical co-processing of fine powders with small quantities of magnesium stearate can radically change the behaviour of fine lactose powders. We report investigations of the basic characteristics of such powders, which have undergone mechanofusion with surface modifying additives, and compare these to unmodified powders, and powders subjected to conventional blending. The study looked at both flow characteristics, as well as fluidization behaviours of a model powder, with median diameter of 8A?m. A powder rheometer was used to probe flow and cohesion properties and these analyses are used to improve understanding of formulation performance. This work indicated that a substantial improvement in flow and fluidization behaviours could be achieved for fine lactose powders within the specific size range by appropriate surface modification. In addition, we observed behaviour changes that appear to derive from changes in packing density and inter-particulate cohesion. The observations have significant implications for future formulation optimisation, and support a Quality by Design formulation approach to product development risk management.",
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Morton, DAV, Zhou, Q, Armstrong, B, Larson, IC & Stewart, PJ 2009, Surface engineering to improve the flowability and fluidization of a cohesive powder. in T Heyns, M Ang, C Butler, P Hay, R Kelson, J Langford, YK Leong, P McEwen, D Montgomery, P Snowsill & M Tade (eds), CHEMECA 2009. Engineers Australia, Australia, pp. CD - CD, Chemeca: Australasian Conference on Chemical Engineering 2009, Perth, Australia, 1/01/09.

Surface engineering to improve the flowability and fluidization of a cohesive powder. / Morton, David Alexander Vodden; Zhou, Qi; Armstrong, B; Larson, Ian Clair; Stewart, Peter James.

CHEMECA 2009. ed. / T Heyns; M Ang; C Butler; P Hay; R Kelson; J Langford; Y K Leong; P McEwen; D Montgomery; P Snowsill; M Tade. Australia : Engineers Australia, 2009. p. CD - CD.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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N2 - Fine pharmaceutical powder formulations must exhibit satisfactory powder flow during production, transportation and administration. We have shown that mechanical co-processing of fine powders with small quantities of magnesium stearate can radically change the behaviour of fine lactose powders. We report investigations of the basic characteristics of such powders, which have undergone mechanofusion with surface modifying additives, and compare these to unmodified powders, and powders subjected to conventional blending. The study looked at both flow characteristics, as well as fluidization behaviours of a model powder, with median diameter of 8A?m. A powder rheometer was used to probe flow and cohesion properties and these analyses are used to improve understanding of formulation performance. This work indicated that a substantial improvement in flow and fluidization behaviours could be achieved for fine lactose powders within the specific size range by appropriate surface modification. In addition, we observed behaviour changes that appear to derive from changes in packing density and inter-particulate cohesion. The observations have significant implications for future formulation optimisation, and support a Quality by Design formulation approach to product development risk management.

AB - Fine pharmaceutical powder formulations must exhibit satisfactory powder flow during production, transportation and administration. We have shown that mechanical co-processing of fine powders with small quantities of magnesium stearate can radically change the behaviour of fine lactose powders. We report investigations of the basic characteristics of such powders, which have undergone mechanofusion with surface modifying additives, and compare these to unmodified powders, and powders subjected to conventional blending. The study looked at both flow characteristics, as well as fluidization behaviours of a model powder, with median diameter of 8A?m. A powder rheometer was used to probe flow and cohesion properties and these analyses are used to improve understanding of formulation performance. This work indicated that a substantial improvement in flow and fluidization behaviours could be achieved for fine lactose powders within the specific size range by appropriate surface modification. In addition, we observed behaviour changes that appear to derive from changes in packing density and inter-particulate cohesion. The observations have significant implications for future formulation optimisation, and support a Quality by Design formulation approach to product development risk management.

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Morton DAV, Zhou Q, Armstrong B, Larson IC, Stewart PJ. Surface engineering to improve the flowability and fluidization of a cohesive powder. In Heyns T, Ang M, Butler C, Hay P, Kelson R, Langford J, Leong YK, McEwen P, Montgomery D, Snowsill P, Tade M, editors, CHEMECA 2009. Australia: Engineers Australia. 2009. p. CD - CD