Projects per year
Bioinspired self-assembly offers a way to create novel functional materials from simple, easy-to-synthesize building blocks. Peptides, in particular, are frequently used in the design of self-assembled materials for their structural properties and the ability for supramolecular ?lock and key? type recognition based on H-bonding networks and dispersion interactions. We have previously reported the head-to-tail self-assembly of N-terminal acetylated ?-peptides into helical fibrils through a supramolecular three point H-bonding motif, and the superstructures formed from inter-fibril interactions. Here we show that the superstructure morphology of a self-assembled ?3-peptide, Ac-?3[LIA], can be tuned to present a range of morphologies by the appropriate solvent medium. From the same monomer we succeeded in creating straight compact ?nano-beams?, self-spun threads and complex, dendritic, hierarchical structures. The variation in geometries is therefore achieved through careful switching and tuning of the relative strengths of the inter-fibril H-bonding, van der Waals and solvophobic interactions.
|Pages (from-to)||3280 - 3287|
|Number of pages||8|
|Journal||New Journal of Chemistry|
|Publication status||Published - 2015|
- 1 Finished
The Design and Synthesis of Inhibitors of HIV Budding
Aguilar, M. & Shenu-Xhilaga, M.
Australian Research Council (ARC)
4/01/10 → 31/12/12