Suppression of cardiac altemans by the alternating-period feedback control

Shiuan Ni Liang; Pik Yin Lai

doi:10.1109/IECBES.2016.7843531

Suppression of cardiac altemans by the alternating-period feedback control

Shiuan Ni Liang, Pik Yin Lai

Malaysia Sch of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

1 Citation (Scopus)

Abstract

Prolonged untreated cardiac alternans may lead to ventricular tachycardia, ventricular fibrillation or sudden cardiac death. Thus, it is important to develop an effective method for controlling alternans. In this paper, the suppression of cardiac alternans is studied using the recently proposed alternating-period feedback control scheme. Numerical simulations are performed on the Luo-Rudy dynamic (LRd) model for single cell. We showed that the action potential duration alternans and intracellular calcium alternans are significantly suppressed after the control is applied. In particular, our result suggests that the contractile force is more balanced from beat to beat after the alternans is reduced.

Original language	English
Title of host publication	IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	657-659
Number of pages	3
ISBN (Electronic)	9781467377911
DOIs	https://doi.org/10.1109/IECBES.2016.7843531
Publication status	Published - 2016
Event	IEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016 - Kuala Lumpur, Malaysia Duration: 4 Dec 2016 → 8 Dec 2016 https://ieeexplore.ieee.org/xpl/conhome/7829191/proceeding (Proceedings)

Conference

Conference	IEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016
Abbreviated title	IECBES 2016
Country/Territory	Malaysia
City	Kuala Lumpur
Period	4/12/16 → 8/12/16
Internet address	https://ieeexplore.ieee.org/xpl/conhome/7829191/proceeding (Proceedings)

Keywords

alternans
APD
calcium
feedback control
LRd
T+T-

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10.1109/IECBES.2016.7843531

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title = "Suppression of cardiac altemans by the alternating-period feedback control",

abstract = "Prolonged untreated cardiac alternans may lead to ventricular tachycardia, ventricular fibrillation or sudden cardiac death. Thus, it is important to develop an effective method for controlling alternans. In this paper, the suppression of cardiac alternans is studied using the recently proposed alternating-period feedback control scheme. Numerical simulations are performed on the Luo-Rudy dynamic (LRd) model for single cell. We showed that the action potential duration alternans and intracellular calcium alternans are significantly suppressed after the control is applied. In particular, our result suggests that the contractile force is more balanced from beat to beat after the alternans is reduced.",

keywords = "alternans, APD, calcium, feedback control, LRd, T+T-",

author = "Liang, {Shiuan Ni} and Lai, {Pik Yin}",

note = "Funding Information: Part of this work is supported by the Ministry of Science and Technology research grant of Taiwan R.O.C. Publisher Copyright: {\textcopyright} 2016 IEEE. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.; IEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016, IECBES 2016 ; Conference date: 04-12-2016 Through 08-12-2016",

year = "2016",

doi = "10.1109/IECBES.2016.7843531",

language = "English",

pages = "657--659",

booktitle = "IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

url = "https://ieeexplore.ieee.org/xpl/conhome/7829191/proceeding",

}

Liang, SN & Lai, PY 2016, Suppression of cardiac altemans by the alternating-period feedback control. in IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences. IEEE, Institute of Electrical and Electronics Engineers, pp. 657-659, IEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016, Kuala Lumpur, Malaysia, 4/12/16. https://doi.org/10.1109/IECBES.2016.7843531

Suppression of cardiac altemans by the alternating-period feedback control. / Liang, Shiuan Ni; Lai, Pik Yin.

IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences. IEEE, Institute of Electrical and Electronics Engineers, 2016. p. 657-659.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Suppression of cardiac altemans by the alternating-period feedback control

AU - Liang, Shiuan Ni

AU - Lai, Pik Yin

N1 - Funding Information: Part of this work is supported by the Ministry of Science and Technology research grant of Taiwan R.O.C. Publisher Copyright: © 2016 IEEE. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2016

Y1 - 2016

N2 - Prolonged untreated cardiac alternans may lead to ventricular tachycardia, ventricular fibrillation or sudden cardiac death. Thus, it is important to develop an effective method for controlling alternans. In this paper, the suppression of cardiac alternans is studied using the recently proposed alternating-period feedback control scheme. Numerical simulations are performed on the Luo-Rudy dynamic (LRd) model for single cell. We showed that the action potential duration alternans and intracellular calcium alternans are significantly suppressed after the control is applied. In particular, our result suggests that the contractile force is more balanced from beat to beat after the alternans is reduced.

AB - Prolonged untreated cardiac alternans may lead to ventricular tachycardia, ventricular fibrillation or sudden cardiac death. Thus, it is important to develop an effective method for controlling alternans. In this paper, the suppression of cardiac alternans is studied using the recently proposed alternating-period feedback control scheme. Numerical simulations are performed on the Luo-Rudy dynamic (LRd) model for single cell. We showed that the action potential duration alternans and intracellular calcium alternans are significantly suppressed after the control is applied. In particular, our result suggests that the contractile force is more balanced from beat to beat after the alternans is reduced.

KW - alternans

KW - APD

KW - calcium

KW - feedback control

KW - LRd

KW - T+T-

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BT - IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences

PB - IEEE, Institute of Electrical and Electronics Engineers

T2 - IEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016

Y2 - 4 December 2016 through 8 December 2016

ER -

Suppression of cardiac altemans by the alternating-period feedback control

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