Suppression of cardiac altemans by the alternating-period feedback control

Shiuan Ni Liang, Pik Yin Lai

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1 Citation (Scopus)


Prolonged untreated cardiac alternans may lead to ventricular tachycardia, ventricular fibrillation or sudden cardiac death. Thus, it is important to develop an effective method for controlling alternans. In this paper, the suppression of cardiac alternans is studied using the recently proposed alternating-period feedback control scheme. Numerical simulations are performed on the Luo-Rudy dynamic (LRd) model for single cell. We showed that the action potential duration alternans and intracellular calcium alternans are significantly suppressed after the control is applied. In particular, our result suggests that the contractile force is more balanced from beat to beat after the alternans is reduced.

Original languageEnglish
Title of host publicationIECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages3
ISBN (Electronic)9781467377911
Publication statusPublished - 2016
EventIEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016 - Kuala Lumpur, Malaysia
Duration: 4 Dec 20168 Dec 2016 (Proceedings)


ConferenceIEEE-EMBS International Conference on Biomedical Engineering and Sciences (IECBES) 2016
Abbreviated titleIECBES 2016
CityKuala Lumpur
Internet address


  • alternans
  • APD
  • calcium
  • feedback control
  • LRd
  • T+T-

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