Engineering the wettability of zero-dimensional (0D) materials (particles, powders and agglomerates) is a key issue in applications such as dissolution, dispersion, granulation, coating, drying and so on. In the past, the superwettability of 3-dimensional (3D), 2-dimensional (2D) and 1-dimensional (1D) materials has been intensively studied. However, the superwettability of 0D materials has received limited attention. It is often investigated as a “collective effect” contributed by many closely packed particles, rather than individual ones. This perspective article reviews the current state of understanding in this area. The definition of superwettable 0D materials is first discussed. Some fundamental rules for understanding 0D superwettability are proposed. Then, methods for investigating the superwettable state of 0D materials are briefly introduced, and the potential applications of superwettable 0D materials are described. Finally, the future development of superwettable 0D materials is discussed.