Superradiant Cancer Hyperthermia Using a Buckyball Assembly of Quantum Dot Emitters

Sudaraka Mallawaarachchi, Malin Premaratne, Philip K. Maini

Research output: Contribution to journalArticleResearchpeer-review

Abstract

With the emergence of nanomedicine, targeted hyperthermia has a high potential of becoming a first-line cancer treatment modality. However, hyperthermia needs to be precisely controlled to avoid damaging adjacent healthy tissues. Due to the uncontrollable transfer of heat from the tumor boundary to healthy tissues, it is extremely difficult to control the temperature increase. As a solution, in this paper, we propose using a superradiant emitter assembly to deliver an ephemeral and powerful thermal pulse to enhance cancer hyperthermia by reducing damage to healthy tissues. Our assembly comprises quantum dot emitters arranged in the shape of a buckyball. We obtain the criteria for our assembly to be superradiant and prove that it is possible to control the superradiance using an external electric field. We analytically obtain expressions for the assembly dynamics and conduct thermal studies using a simple breast cancer model constructed using experimental parameters. Our results indicate that using a series of superradiant pulses can enhance cancer hyperthermia by minimizing the damage to adjacent healthy tissues.

Original languageEnglish
Article number7101508
Number of pages8
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume25
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Coupled mode analysis
  • nanotechnology
  • photon radiation effects

Cite this

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abstract = "With the emergence of nanomedicine, targeted hyperthermia has a high potential of becoming a first-line cancer treatment modality. However, hyperthermia needs to be precisely controlled to avoid damaging adjacent healthy tissues. Due to the uncontrollable transfer of heat from the tumor boundary to healthy tissues, it is extremely difficult to control the temperature increase. As a solution, in this paper, we propose using a superradiant emitter assembly to deliver an ephemeral and powerful thermal pulse to enhance cancer hyperthermia by reducing damage to healthy tissues. Our assembly comprises quantum dot emitters arranged in the shape of a buckyball. We obtain the criteria for our assembly to be superradiant and prove that it is possible to control the superradiance using an external electric field. We analytically obtain expressions for the assembly dynamics and conduct thermal studies using a simple breast cancer model constructed using experimental parameters. Our results indicate that using a series of superradiant pulses can enhance cancer hyperthermia by minimizing the damage to adjacent healthy tissues.",
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Superradiant Cancer Hyperthermia Using a Buckyball Assembly of Quantum Dot Emitters. / Mallawaarachchi, Sudaraka; Premaratne, Malin; Maini, Philip K.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 25, No. 2, 7101508, 01.03.2019.

Research output: Contribution to journalArticleResearchpeer-review

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