Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury

Johannes Riegler, Aaron Liew, Sean O. Hynes, Daniel Ortega, Timothy O'Brien, Richard M. Day, Toby Richards, Faisal Sharif, Quentin A. Pankhurst, Mark F. Lythgoe

Research output: Contribution to journalArticleResearchpeer-review

122 Citations (Scopus)

Abstract

Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery.

Original languageEnglish
Pages (from-to)1987-1994
Number of pages8
JournalBiomaterials
Volume34
Issue number8
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Keywords

  • Catheter
  • Magnetic targeting
  • Nanoparticle
  • Restenosis
  • Stem cell

Cite this