Supercritical carbon dioxide extraction of α-mangostin from mangosteen pericarp with virgin coconut oil as co-extractant and in-vitro bio-accessibility measurement

Wan Jun Lee, Chea Chi Ng, Jin Shuen Ng, Richard Lee Smith, Siew Lee Kok, Yen Yi Hee, Sin Yee Lee, Wei Kiat Tan, Nur Hanani Zainal Abidin, Sarina Abdul Halim Lim, Gun Hean Chong

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12 Citations (Scopus)


This work aims to develop a method for producing α-mangostin that has high bio-accessibility through the use of supercritical carbon dioxide (scCO2) extraction of mangosteen pericarp extract (MPE) with virgin coconut oil (VCO) as co-extractant. Extractions with scCO2 were carried out at 30 MPa to 40 MPa, 60 °C, CO2 flow rate of 1.7 g/min and co-extractant VCO (0% to 20%). MPE yield and extraction yield increased with the amount of co-extractant added. The highest yield of MPE obtained was 17% at conditions of 35 MPa with 20% of VCO. The scCO2 MPE had higher bio-accessibility for α-mangostin (91%) than α-mangostin obtained by extraction with ethanol (30%) or hexane (50%). Thus, supercritical CO2 extraction used with virgin coconut oil co-extractant provides a method for producing high bio-accessible α-mangostin from mangosteen pericarp extract.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalProcess Biochemistry
Publication statusPublished - Dec 2019


  • Bio-accessibility
  • Co-extractant
  • Garcinia mangostana Linn
  • Supercritical fluid extraction
  • Virgin coconut oil
  • Xanthone

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