[3H]Paroxetine Binding Is Altered in the Hippocampus but Not the Frontal Cortex or Caudate Nucleus from Subjects with Schizophrenia

Brian Dean, Kenneth Opeskin, Geoffrey Pavey, Lee Naylor, Christine Hill, Nicholas Keks, David L. Copolov

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Abstract

Abstract: [3H]Paroxetine binding to particulate membrane from tissue, obtained at autopsy, from the hippocampus, frontal cortex, and caudate nucleus from subjects who had or had not had schizophrenia was measured. The density of [3H]paroxetine binding to membranes from subjects who had or had not had schizophrenia did not differ. Similarly, the affinity of [3H]paroxetine binding in the frontal cortex and caudate nucleus was not different. By contrast, the affinity of [3H]paroxetine binding to hippocampal membrane from subjects who had schizophrenia was significantly lower than the affinity of binding for the nonschizophrenic subjects (0.40 ± 0.06 vs. 0.26 ± 0.02; p < 0.05). As [3H]paroxetine binds to the serotonin transporter, these data suggest that the serotonin transporter is altered in the hippocampus in subjects with schizophrenia.

Original languageEnglish
Pages (from-to)1197-1202
Number of pages6
JournalJournal of Neurochemistry
Volume64
Issue number3
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • Caudate nucleus
  • Frontal cortex
  • Hippocampus
  • Paroxetine
  • Schizophrenia
  • Serotonin transporter

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