1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1

Biswaranjan Mohanty, Ana P G Silva, Joel P. Mackay, Daniel P. Ryan

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Abstract

Chromatin remodelling proteins are an essential family of eukaryotic proteins. They harness the energy from ATP hydrolysis and apply it to alter chromatin structure in order to regulate all aspects of genome biology. Chromodomain helicase DNA-binding protein 1 (CHD1) is one such remodelling protein that has specialised nucleosome organising abilities and is conserved across eukaryotes. CHD1 possesses a pair of tandem chromodomains that directly precede the core catalytic Snf2 helicase-like domain, and a C-terminal SANT-SLIDE DNA-binding domain. We have identified an additional conserved domain in the C-terminal region of CHD1. Here, we report the backbone and side chain resonance assignments for this domain from human CHD1 at pH 6.5 and 25 °C (BMRB No. 25638).

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalBiomolecular NMR Assignments
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • C-terminal domain
  • CHD1
  • Chromatin remodelling
  • Nucleosomes

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