Sulfur - fluorine bond in PET radiochemistry

Giancarlo Pascali, Lidia Matesic, Bo Zhang, Andrew T. King, Andrea J. Robinson, Alison T. Ung, Benjamin H. Fraser

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)


The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications.

Original languageEnglish
Article number9
Number of pages18
JournalEJNMMI Radiopharmacy and Chemistry
Issue number1
Publication statusPublished - 1 Dec 2017


  • F
  • Deoxyfluorination
  • Fluoride relay
  • Fluorosulfate
  • PET
  • Sulfonyl fluoride
  • Sulfur-fluorine bond
  • Sulfurhexafluoride

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