Sulfa drugs strike more than once

Onisha G Patel; Eddy K Mberu; Alexis M Nzila; Ian G Macreadie

doi:10.1016/j.pt.2003.10.009

Sulfa drugs strike more than once

Onisha G Patel, Eddy K Mberu, Alexis M Nzila, Ian G Macreadie

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.

Original language	English
Pages (from-to)	1 - 3
Number of pages	3
Journal	Trends in Parasitology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.pt.2003.10.009
Publication status	Published - 2004

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10.1016/j.pt.2003.10.009

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abstract = "Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.",

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AU - Patel, Onisha G

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AU - Nzila, Alexis M

AU - Macreadie, Ian G

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AB - Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.

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JO - Trends in Parasitology

JF - Trends in Parasitology

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Sulfa drugs strike more than once

Abstract

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