Sulfa drugs strike more than once

Onisha G Patel, Eddy K Mberu, Alexis M Nzila, Ian G Macreadie

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Abstract

Sulfa drugs are well known blockers of folate synthesis, acting as competitive inhibitors of p-aminobenzoate (pABA). Their mimicry of pABA is so complete that they can also condense with 2-amino-4-hydroxy-6-hydroxymethyl-7,8 dihydropteridine pyrophosphate to form sulfa-dihydropteroate (sulfa-DHP), which are inhibitory through competition with dihydrofolate. This suggests that, in addition to dihydropteroate synthase, there are still undiscovered determinants involved in sulfa drug resistance. Furthermore, novel drugs based on the DHP analogues could be added to the armory of antifolate drugs.
Original languageEnglish
Pages (from-to)1 - 3
Number of pages3
JournalTrends in Parasitology
Volume20
Issue number1
DOIs
Publication statusPublished - 2004

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