La conducta suicida se asocia a una reducción el área del cuerpo calloso

Translated title of the contribution: Suicidal behavior is associated with reduced corpus callosum area

Fabienne Cyprien, Philippe Courtet, Alain Malafosse, Jerome Maller, Chantal Meslin, Alain Bonafé, Emmanuelle Le Bars, Nicolas Menjot De Champfleur, Karen Ritchie, Sylvaine Artero

Research output: Contribution to journalArticleResearch


Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric andmood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the 3 groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (P =.020) and HC (P =.010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.

Translated title of the contributionSuicidal behavior is associated with reduced corpus callosum area
Original languageSpanish
Pages (from-to)31-38
Number of pages8
JournalPsiquiatria Biologica
Issue number2
Publication statusPublished - Apr 2012


  • Corpus callosum
  • Magnetic resonance imaging
  • Suicidal behavior

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