Successful treatment of Epstein-Barr virus encephalitis in the setting of HIV-associated neurocognitive disorder: a diagnostic and therapeutic challenge

Janine Maree Trevillyan, Andrew A Mahony, Catriona Ann McLean, Jennifer F Hoy

Research output: Contribution to journalArticleOther

8 Citations (Scopus)


We report a challenging case of HIV-associated neurocognitive disorder with superimposed Epstein-Barr virus (EBV) encephalitis. The patient presented with an abnormal MRI brain scan, and EBV DNA that was detected in the cerebrospinal luid and brain biopsy, which also demonstrated histopathological indings consistent with the diagnosis. This occurred on the background of a 12-month period of gradual cognitive decrease secondary to HIV-associated dementia. Invasive testing was required to reach the diagnosis in this case, highlighting the importance of thorough investigation of neurological impairment in HIV-positive patients. Clinicopathological recovery was achieved through optimization of antiretroviral therapy and use of valganciclovir.
Original languageEnglish
Pages (from-to)257 - 261
Number of pages5
JournalAntiviral Therapy
Issue number2
Publication statusPublished - 2013

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