TY - JOUR
T1 - Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
AU - Boyd, Ben J.
AU - Bergström, Christel A.S.
AU - Vinarov, Zahari
AU - Kuentz, Martin
AU - Brouwers, Joachim
AU - Augustijns, Patrick
AU - Brandl, Martin
AU - Bernkop-Schnürch, Andreas
AU - Shrestha, Neha
AU - Préat, Véronique
AU - Müllertz, Anette
AU - Bauer-Brandl, Annette
AU - Jannin, Vincent
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.
AB - Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.
KW - Bioavailability
KW - Drug delivery
KW - Formulation
KW - Lipid formulations
KW - Poorly water-soluble drugs
KW - Solid state
UR - https://www.scopus.com/pages/publications/85068036241
U2 - 10.1016/j.ejps.2019.104967
DO - 10.1016/j.ejps.2019.104967
M3 - Article
AN - SCOPUS:85068036241
SN - 0928-0987
VL - 137
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
M1 - 104967
ER -