Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

Ary Hoffmann, Brian Montgomery, Jean Popovici, Inaki Iturbe-Ormaetxe, Petrina Johnson, F Muzzi, M Greenfield, M Durkan, Yi San Leong, Yi Dong, H Cook, Jason Axford, A Callahan, Nichola Kenny, C Omodei, Elizabeth McGraw, Peter Ryan, Scott Ritchie, Michael Turelli, Scott Leslie O'Neill

Research output: Contribution to journalArticleResearchpeer-review

820 Citations (Scopus)

Abstract

Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations(1). Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility(2). When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan(3-6). Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster(7), successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency
Original languageEnglish
Pages (from-to)454 - 459
Number of pages6
JournalNature
Volume476
Issue number7361
DOIs
Publication statusPublished - 2011

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