Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

Ary Hoffmann; Brian Montgomery; Jean Popovici; Inaki Iturbe-Ormaetxe; Petrina Johnson; F Muzzi; M Greenfield; M Durkan; Yi San Leong; Yi Dong; H Cook; Jason Axford; A Callahan; Nichola Kenny; C Omodei; Elizabeth McGraw; Peter Ryan; Scott Ritchie; Michael Turelli; Scott Leslie O'Neill

doi:10.1038/nature10356

Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

Ary Hoffmann, Brian Montgomery, Jean Popovici, Inaki Iturbe-Ormaetxe, Petrina Johnson, F Muzzi, M Greenfield, M Durkan, Yi San Leong, Yi Dong, H Cook, Jason Axford, A Callahan, Nichola Kenny, C Omodei, Elizabeth McGraw, Peter Ryan, Scott Ritchie, Michael Turelli, Scott Leslie O'Neill

School of Biological Sciences

Research output: Contribution to journal › Article › Research › peer-review

1098 Citations (Scopus)

Abstract

Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations(1). Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility(2). When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan(3-6). Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster(7), successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency

Original language	English
Pages (from-to)	454 - 459
Number of pages	6
Journal	Nature
Volume	476
Issue number	7361
DOIs	https://doi.org/10.1038/nature10356
Publication status	Published - 2011

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Hoffmann, A., Montgomery, B., Popovici, J., Iturbe-Ormaetxe, I., Johnson, P., Muzzi, F., Greenfield, M., Durkan, M., Leong, Y. S., Dong, Y., Cook, H., Axford, J., Callahan, A., Kenny, N., Omodei, C., McGraw, E., Ryan, P., Ritchie, S., Turelli, M., & O'Neill, S. L. (2011). Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature, 476(7361), 454 - 459. https://doi.org/10.1038/nature10356

@article{2054fda842554eb88c4ee8b7e1db03fe,

title = "Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission",

abstract = "Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations(1). Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility(2). When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan(3-6). Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster(7), successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency",

author = "Ary Hoffmann and Brian Montgomery and Jean Popovici and Inaki Iturbe-Ormaetxe and Petrina Johnson and F Muzzi and M Greenfield and M Durkan and Leong, {Yi San} and Yi Dong and H Cook and Jason Axford and A Callahan and Nichola Kenny and C Omodei and Elizabeth McGraw and Peter Ryan and Scott Ritchie and Michael Turelli and O'Neill, {Scott Leslie}",

year = "2011",

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volume = "476",

pages = "454 -- 459",

journal = "Nature",

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Hoffmann, A, Montgomery, B, Popovici, J, Iturbe-Ormaetxe, I, Johnson, P, Muzzi, F, Greenfield, M, Durkan, M, Leong, YS, Dong, Y, Cook, H, Axford, J, Callahan, A, Kenny, N, Omodei, C, McGraw, E, Ryan, P, Ritchie, S, Turelli, M & O'Neill, SL 2011, 'Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission', Nature, vol. 476, no. 7361, pp. 454 - 459. https://doi.org/10.1038/nature10356

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T1 - Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

AU - Hoffmann, Ary

AU - Montgomery, Brian

AU - Popovici, Jean

AU - Iturbe-Ormaetxe, Inaki

AU - Johnson, Petrina

AU - Muzzi, F

AU - Greenfield, M

AU - Durkan, M

AU - Leong, Yi San

AU - Dong, Yi

AU - Cook, H

AU - Axford, Jason

AU - Callahan, A

AU - Kenny, Nichola

AU - Omodei, C

AU - McGraw, Elizabeth

AU - Ryan, Peter

AU - Ritchie, Scott

AU - Turelli, Michael

AU - O'Neill, Scott Leslie

PY - 2011

Y1 - 2011

N2 - Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations(1). Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility(2). When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan(3-6). Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster(7), successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency

AB - Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations(1). Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility(2). When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan(3-6). Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster(7), successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency

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U2 - 10.1038/nature10356

DO - 10.1038/nature10356

M3 - Article

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VL - 476

SP - 454

EP - 459

JO - Nature

JF - Nature

IS - 7361

ER -

Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

Abstract

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