Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus

Tim G. Littlejohn; Ian T. Paulsen; Matthew T. Gillespie; Jan M. Tennent; Melvin Midgley; I. Gwyn Jones; Amarjit S. Purewal; Ronald A. Skurray

doi:10.1016/0378-1097(92)90439-U

Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus

Tim G. Littlejohn, Ian T. Paulsen, Matthew T. Gillespie, Jan M. Tennent, Melvin Midgley, I. Gwyn Jones, Amarjit S. Purewal, Ronald A. Skurray

Microbiology

Research output: Contribution to journal › Article › Research › peer-review

189 Citations (Scopus)

Abstract

Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes code efflux systems that rely on proton motive force.

Original language	English
Pages (from-to)	259-265
Number of pages	7
Journal	FEMS Microbiology Letters
Volume	95
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-1097(92)90439-U
Publication status	Published - 15 Aug 1992

Keywords

Antiseptic resistance
qac Gene
Quaternary ammonium compounds
Staphylococcus aureus

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10.1016/0378-1097(92)90439-U

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abstract = "Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes code efflux systems that rely on proton motive force.",

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AU - Littlejohn, Tim G.

AU - Paulsen, Ian T.

AU - Gillespie, Matthew T.

AU - Tennent, Jan M.

AU - Midgley, Melvin

AU - Jones, I. Gwyn

AU - Purewal, Amarjit S.

AU - Skurray, Ronald A.

PY - 1992/8/15

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N2 - Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes code efflux systems that rely on proton motive force.

AB - Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes code efflux systems that rely on proton motive force.

KW - Antiseptic resistance

KW - qac Gene

KW - Quaternary ammonium compounds

KW - Staphylococcus aureus

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SN - 0378-1097

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EP - 265

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 2-3

ER -

Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus

Abstract

Keywords

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