Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus

Tim G. Littlejohn, Ian T. Paulsen, Matthew T. Gillespie, Jan M. Tennent, Melvin Midgley, I. Gwyn Jones, Amarjit S. Purewal, Ronald A. Skurray

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Clinical isolates of Staphylococcus aureus carry various antiseptic and disinfectant resistance determinants (qac genes) on a variety of plasmids. The biochemistry and specificity of these resistance genes in S. aureus is the subject of this report. The qac genes were separated into two families on the basis of resistance profiles and DNA homology. Isotopic and fluorimetric assays demonstrated that the qac genes code efflux systems that rely on proton motive force.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalFEMS Microbiology Letters
Issue number2-3
Publication statusPublished - 15 Aug 1992


  • Antiseptic resistance
  • qac Gene
  • Quaternary ammonium compounds
  • Staphylococcus aureus

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