Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy- indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian, Raju Suresh Kumar, Hasnah Osman, Elumalai Manogaran

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117 Citations (Scopus)


Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC50 0.10 μmol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD.

Original languageEnglish
Pages (from-to)7064-7066
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number23
Publication statusPublished - 1 Dec 2010
Externally publishedYes


  • 1,3-Dipolar cycloaddition
  • Acetyl cholinesterase
  • AChE inhibitor
  • Alzheimer diseases
  • Azomethine ylide

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