Substandard application of preimplantation genetic screening may interfere with its clinical success

Santiago Munne, Luca Gianaroli, Ilan Tur-Kaspa, Cristina Magli, Mireia Sandalinas, Jamie Grifo, David Stephen Cram, Semra Kahraman, Yury Verlinsky, Joe L Simpson

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    92 Citations (Scopus)


    The intent of this study was to evaluate a recent randomized clinical trial evaluating the effect of preimplantation genetic screening (PGS) that reports a negative effect on pregnancy outcome. This article reviews appropriate PGS techniques and how they differ from the trial in question. A closer look at the clinical trial in question reveals significant lack of expertise in biopsy, cell fixation, genetic analysis, and patient selection. At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial.
    Original languageEnglish
    Pages (from-to)781 - 784
    Number of pages4
    JournalFertility and Sterility
    Issue number4
    Publication statusPublished - 2007

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