Subfornical organ lesion decreases sodium appetite in the sodium-depleted rat

R. S. Weisinger; D. A. Denton; R. Di Nicolantonio; D. K. Hards; M. J. McKinley; B. Oldfield; P. G. Osborne

doi:10.1016/0006-8993(90)90245-7

Subfornical organ lesion decreases sodium appetite in the sodium-depleted rat

R. S. Weisinger, D. A. Denton, R. Di Nicolantonio, D. K. Hards, M. J. McKinley, B. Oldfield, P. G. Osborne

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

The effect of subfornical organ (SFO) lesion on various models of ingestive behaviour was investigated in rats. Intake of water after 24 h water deprivation or systemic administration of hypertonic NaCl were not altered by SFO lesions. Intake of food or water after 24 h of food deprivation were not altered by SFO lesions. Intake of NaCl after furosemide-induced Na depletion was decreased by ablation of the SFO. This decrease in Na intake was ameliorated by pretreatment with a low dose of captopril. These results suggest that the SFO is involved in Na intake after Na depletion, but not in water or food intake following periods of water or food deprivation, respectively. The observation that a low dose of captopril can eliminate the decrease in Na appetite which occurred subsequent to SFO lesion suggests that other brain areas may also participate in Na-depletion-induced Na appetite.

Original language	English
Pages (from-to)	23-30
Number of pages	8
Journal	Brain Research
Volume	526
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(90)90245-7
Publication status	Published - 27 Aug 1990
Externally published	Yes

Keywords

Circumventricular organ
Converting enzyme inhibition
Drinking behavior
Eating behavior
Furosemide
Hunger
Ingestive behavior

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10.1016/0006-8993(90)90245-7

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title = "Subfornical organ lesion decreases sodium appetite in the sodium-depleted rat",

abstract = "The effect of subfornical organ (SFO) lesion on various models of ingestive behaviour was investigated in rats. Intake of water after 24 h water deprivation or systemic administration of hypertonic NaCl were not altered by SFO lesions. Intake of food or water after 24 h of food deprivation were not altered by SFO lesions. Intake of NaCl after furosemide-induced Na depletion was decreased by ablation of the SFO. This decrease in Na intake was ameliorated by pretreatment with a low dose of captopril. These results suggest that the SFO is involved in Na intake after Na depletion, but not in water or food intake following periods of water or food deprivation, respectively. The observation that a low dose of captopril can eliminate the decrease in Na appetite which occurred subsequent to SFO lesion suggests that other brain areas may also participate in Na-depletion-induced Na appetite.",

keywords = "Circumventricular organ, Converting enzyme inhibition, Drinking behavior, Eating behavior, Furosemide, Hunger, Ingestive behavior",

author = "Weisinger, {R. S.} and Denton, {D. A.} and {Di Nicolantonio}, R. and Hards, {D. K.} and McKinley, {M. J.} and B. Oldfield and Osborne, {P. G.}",

year = "1990",

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AU - Weisinger, R. S.

AU - Denton, D. A.

AU - Di Nicolantonio, R.

AU - Hards, D. K.

AU - McKinley, M. J.

AU - Oldfield, B.

AU - Osborne, P. G.

PY - 1990/8/27

Y1 - 1990/8/27

N2 - The effect of subfornical organ (SFO) lesion on various models of ingestive behaviour was investigated in rats. Intake of water after 24 h water deprivation or systemic administration of hypertonic NaCl were not altered by SFO lesions. Intake of food or water after 24 h of food deprivation were not altered by SFO lesions. Intake of NaCl after furosemide-induced Na depletion was decreased by ablation of the SFO. This decrease in Na intake was ameliorated by pretreatment with a low dose of captopril. These results suggest that the SFO is involved in Na intake after Na depletion, but not in water or food intake following periods of water or food deprivation, respectively. The observation that a low dose of captopril can eliminate the decrease in Na appetite which occurred subsequent to SFO lesion suggests that other brain areas may also participate in Na-depletion-induced Na appetite.

AB - The effect of subfornical organ (SFO) lesion on various models of ingestive behaviour was investigated in rats. Intake of water after 24 h water deprivation or systemic administration of hypertonic NaCl were not altered by SFO lesions. Intake of food or water after 24 h of food deprivation were not altered by SFO lesions. Intake of NaCl after furosemide-induced Na depletion was decreased by ablation of the SFO. This decrease in Na intake was ameliorated by pretreatment with a low dose of captopril. These results suggest that the SFO is involved in Na intake after Na depletion, but not in water or food intake following periods of water or food deprivation, respectively. The observation that a low dose of captopril can eliminate the decrease in Na appetite which occurred subsequent to SFO lesion suggests that other brain areas may also participate in Na-depletion-induced Na appetite.

KW - Circumventricular organ

KW - Converting enzyme inhibition

KW - Drinking behavior

KW - Eating behavior

KW - Furosemide

KW - Hunger

KW - Ingestive behavior

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VL - 526

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JO - Brain Research

JF - Brain Research

IS - 1

ER -

Subfornical organ lesion decreases sodium appetite in the sodium-depleted rat

Abstract

Keywords

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