Subcutaneous drug delivery and the role of the lymphatics

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117 Citations (Scopus)

Abstract

Subcutaneous injections are widely utilised as a delivery route for compounds with limited oral bioavailability or as a means to modify or extend the release profile. In this review, factors affecting absorption from the subcutaneous space are discussed with particular emphasis on differential drug absorption into either the underlying blood or lymphatic capillaries. Formulation and targeted delivery approaches, which utilise the subcutaneous administration route, are reviewed with reference to associated technologies and future challenges. © 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalDrug Discovery Today: Technologies
Volume2
Issue number1
DOIs
Publication statusPublished - 2005

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