TY - JOUR
T1 - Subcutaneous drug delivery and the role of the lymphatics
AU - McLennan, Danielle N
AU - Porter, Christopher John H
AU - Charman, Susan A
PY - 2005
Y1 - 2005
N2 - Subcutaneous injections are widely utilised as a delivery route for compounds with limited oral bioavailability or as a means to modify or extend the release profile. In this review, factors affecting absorption from the subcutaneous space are discussed with particular emphasis on differential drug absorption into either the underlying blood or lymphatic capillaries. Formulation and targeted delivery approaches, which utilise the subcutaneous administration route, are reviewed with reference to associated technologies and future challenges. © 2005 Elsevier Ltd. All rights reserved.
AB - Subcutaneous injections are widely utilised as a delivery route for compounds with limited oral bioavailability or as a means to modify or extend the release profile. In this review, factors affecting absorption from the subcutaneous space are discussed with particular emphasis on differential drug absorption into either the underlying blood or lymphatic capillaries. Formulation and targeted delivery approaches, which utilise the subcutaneous administration route, are reviewed with reference to associated technologies and future challenges. © 2005 Elsevier Ltd. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=21744451953&partnerID=8YFLogxK
U2 - 10.1016/j.ddtec.2005.05.006
DO - 10.1016/j.ddtec.2005.05.006
M3 - Article
SN - 1740-6749
VL - 2
SP - 89
EP - 96
JO - Drug Discovery Today: Technologies
JF - Drug Discovery Today: Technologies
IS - 1
ER -