Subcortical projections to the frontal pole in the marmoset monkey

Kathleen Burman, David Reser, Karyn Richardson, Heidi Gaulke, Katrina Worthy, Marcello Rosa

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Abstract

The subcortical projections to the marmoset frontal pole were mapped with the use of fluorescent tracer injections. The main thalamic projections, which originated in both the magnocellular and parvocellular subdivisions of the mediodorsal nucleus, were topographically organized. Our results suggest the existence of a third, caudal subdivision of this nucleus, which is likely to be homologous to the macaque s pars densocellularis. A substantial, but not topographically organized, projection to Brodmann s area 10 originated in the medial part of the ventral anterior nucleus. Minor thalamic projections originated in the medial pulvinar nucleus and in the midline/intralaminar nuclei. Finally, the posterior thalamic group (including the limitans and suprageniculate nuclei) sent a small projection to rostral area 10 that has not previously been documented in primates. The main extrathalamic projections stemmed from the claustrum, which contained as many as 50 of all subcortical labelled neurons. Minor connections originated in the hypothalamus (mainly in the lateral anterior and lateral tuberal regions), dorsal periaqueductal grey matter, basal forebrain (nucleus basalis of Meynert and horizontal limb of the diagonal band of Broca), and amygdala (basal, accessory basal and lateral nuclei). The present results, combined with recent data on the cortical projections to area 10, reveal the frontal pole as a region that integrates information from multiple neural processing systems, including high-level sensory, limbic and working memory-related structures. Although the pattern of subcortical projections is similar to that previously described in the macaque, suggesting a homologous organization, the present data also suggest functional distinctions between medial and lateral sectors of area 10.
Original languageEnglish
Pages (from-to)303 - 319
Number of pages17
JournalEuropean Journal of Neuroscience
Volume34
Issue number2
DOIs
Publication statusPublished - 2011

Cite this

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title = "Subcortical projections to the frontal pole in the marmoset monkey",
abstract = "The subcortical projections to the marmoset frontal pole were mapped with the use of fluorescent tracer injections. The main thalamic projections, which originated in both the magnocellular and parvocellular subdivisions of the mediodorsal nucleus, were topographically organized. Our results suggest the existence of a third, caudal subdivision of this nucleus, which is likely to be homologous to the macaque s pars densocellularis. A substantial, but not topographically organized, projection to Brodmann s area 10 originated in the medial part of the ventral anterior nucleus. Minor thalamic projections originated in the medial pulvinar nucleus and in the midline/intralaminar nuclei. Finally, the posterior thalamic group (including the limitans and suprageniculate nuclei) sent a small projection to rostral area 10 that has not previously been documented in primates. The main extrathalamic projections stemmed from the claustrum, which contained as many as 50 of all subcortical labelled neurons. Minor connections originated in the hypothalamus (mainly in the lateral anterior and lateral tuberal regions), dorsal periaqueductal grey matter, basal forebrain (nucleus basalis of Meynert and horizontal limb of the diagonal band of Broca), and amygdala (basal, accessory basal and lateral nuclei). The present results, combined with recent data on the cortical projections to area 10, reveal the frontal pole as a region that integrates information from multiple neural processing systems, including high-level sensory, limbic and working memory-related structures. Although the pattern of subcortical projections is similar to that previously described in the macaque, suggesting a homologous organization, the present data also suggest functional distinctions between medial and lateral sectors of area 10.",
author = "Kathleen Burman and David Reser and Karyn Richardson and Heidi Gaulke and Katrina Worthy and Marcello Rosa",
year = "2011",
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language = "English",
volume = "34",
pages = "303 -- 319",
journal = "European Journal of Neuroscience",
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Subcortical projections to the frontal pole in the marmoset monkey. / Burman, Kathleen; Reser, David; Richardson, Karyn; Gaulke, Heidi; Worthy, Katrina; Rosa, Marcello.

In: European Journal of Neuroscience, Vol. 34, No. 2, 2011, p. 303 - 319.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Subcortical projections to the frontal pole in the marmoset monkey

AU - Burman, Kathleen

AU - Reser, David

AU - Richardson, Karyn

AU - Gaulke, Heidi

AU - Worthy, Katrina

AU - Rosa, Marcello

PY - 2011

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N2 - The subcortical projections to the marmoset frontal pole were mapped with the use of fluorescent tracer injections. The main thalamic projections, which originated in both the magnocellular and parvocellular subdivisions of the mediodorsal nucleus, were topographically organized. Our results suggest the existence of a third, caudal subdivision of this nucleus, which is likely to be homologous to the macaque s pars densocellularis. A substantial, but not topographically organized, projection to Brodmann s area 10 originated in the medial part of the ventral anterior nucleus. Minor thalamic projections originated in the medial pulvinar nucleus and in the midline/intralaminar nuclei. Finally, the posterior thalamic group (including the limitans and suprageniculate nuclei) sent a small projection to rostral area 10 that has not previously been documented in primates. The main extrathalamic projections stemmed from the claustrum, which contained as many as 50 of all subcortical labelled neurons. Minor connections originated in the hypothalamus (mainly in the lateral anterior and lateral tuberal regions), dorsal periaqueductal grey matter, basal forebrain (nucleus basalis of Meynert and horizontal limb of the diagonal band of Broca), and amygdala (basal, accessory basal and lateral nuclei). The present results, combined with recent data on the cortical projections to area 10, reveal the frontal pole as a region that integrates information from multiple neural processing systems, including high-level sensory, limbic and working memory-related structures. Although the pattern of subcortical projections is similar to that previously described in the macaque, suggesting a homologous organization, the present data also suggest functional distinctions between medial and lateral sectors of area 10.

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M3 - Article

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JF - European Journal of Neuroscience

SN - 0953-816X

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ER -