Subcompartmentalized Surface-Adhering Polymer Thin Films Toward Drug Delivery Applications

Boon M. Teo, Martin E. Lynge, Leticia Hosta-Rigau, Brigitte Städler

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

This chapter reviews the progress in subcompartmentalized surface-adhering layer-bylayer (LbL) films for substrate-mediated drug delivery (SMDD). It provides an overview of the predominant subcompartments used, namely cyclodextrins (CDs), block copolymer micelles (BCMs), and liposomes. BCMs incorporated within LbL films can be glassy or responsive to environmental stimuli. The chapter discusses the miscellaneous subunits with potential in SMDD. The approaches are reviewed in terms of their assembly followed by their characterization relevant in SMDD. Composite coatings successfully used to deliver (active) compounds to adhering cells are highlighted. The chapter focuses on the few films, which have been tested in vivo, in order to present the progress and impact these subcompartmentalized coatings have made over the past years as well as their potential and remaining challenges for their application in SMDD.

Original languageEnglish
Title of host publicationLayer-by-Layer Films for Biomedical Applications
EditorsCatherine Picart, Frank Caruso, Jean-Claude Voegel
Place of PublicationWeinheim Germany
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Pages207-232
Number of pages26
ISBN (Electronic)9783527675883
ISBN (Print)9783527335893
DOIs
Publication statusPublished - 30 Jan 2015
Externally publishedYes

Keywords

  • Block copolymer micelle (BCM)
  • Cyclodextrin (CD)-containing LbL films
  • Drug delivery applications
  • Liposome-containing LbL films
  • Subcompartmentalized surface-adhering layer-bylayer (LbL) films
  • Substrate-mediated drug delivery (SMDD)

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