Subclinical leaflet thrombosis in transcatheter aortic valve replacement detected by multidetector computed tomography ― A review of current evidence

Hashrul Nizam Zainul Rashid, Adam John Dunbar Brown, Liam McCormick, Ameera S. Amiruddin, Kim K Be, James Donald Cameron, Arthur Nasis, Robert Peter Gooley

Research output: Contribution to journalReview ArticleResearchpeer-review

25 Citations (Scopus)


Subclinical leaflet thrombosis (SLT) following transcatheter aortic valve replacement (TAVR) has been increasingly recognized. SLT has the hallmark features of hypo-attenuated leaflet thickening (HALT) on multidetector computed tomography (MDCT), which may result in hypoattenuation affecting motion (HAM). The actual prevalence of this condition is uncertain, with limited observational registries. SLT has caught the attention of the cardiovascular community because of concerns regarding its clinical sequelae, specifically the potential increased incidence of cerebrovascular events. There are available, albeit sparse, data to suggest that when left untreated, SLT may lead to valve deterioration with potential hemodynamic compromise and potentially clinically overt prostheses thrombosis. Some clinicians have opted to treat patients with SLT with anticoagulation. Although anticoagulation may be a rational treatment option, little data exist on the safety and efficacy of this treatment. This is particularly important considering TAVR patients also have higher bleeding risk than the standard population. In this review, we aim to summarize the current evidence on SLT, explore its pathophysiological mechanism, discuss the current treatment options and future trials that may clarify the optimal antithrombotic strategies of SLT.

Original languageEnglish
Pages (from-to)1735-1742
Number of pages8
JournalCirculation Journal
Issue number7
Publication statusPublished - 1 Jan 2018


  • Aortic stenosis
  • Thrombosis
  • Transcatheter aortic valve replacement/implantation

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