Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand

A multicenter cohort analysis of in-hospital mortality over 15 Years

Andrew A. Udy, Chelsey Vladic, Edward Robert Saxby, Jeremy Cohen, Anthony Delaney, Oliver Flower, Matthew Anstey, Rinaldo Bellomo, David James Cooper, David V. Pilcher, Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

OBJECTIVE:: The primary aim of this study was to describe in-hospital mortality in subarachnoid hemorrhage patients requiring ICU admission. Secondary aims were to identify clinical characteristics associated with inferior outcomes, to compare subarachnoid hemorrhage mortality with other neurological diagnoses, and to explore the variability in subarachnoid hemorrhage standardized mortality ratios. 

DESIGN:: Multicenter, binational, retrospective cohort study. 

SETTING:: Data were extracted from the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. 

PATIENTS:: All available records for the period January 2000 to June 2015. 

INTERVENTIONS:: Nil. 

MEASUREMENTS AND MAIN RESULTS:: A total of 11,327 subarachnoid hemorrhage patients were identified in the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. The overall case fatality rate was 29.2%, which declined from 35.4% in 2000 to 27.2% in 2015 (p = 0.01). Older age, nonoperative admission, mechanical ventilation, higher Acute Physiology and Chronic Health Evaluation III scores, lower Glasgow Coma Scale, and admission prior to 2004 were all associated with lower hospital survival in multivariable analysis (p < 0.05). In comparison with other neurological diagnoses, subarachnoid hemorrhage patients had significantly greater risk-adjusted in-hospital mortality (odds ratio, 1.89 [95% CI, 1.79–2.00]). Utilizing data from the 5 most recent complete years (2010–2014), three sites had higher and four (including the two largest centers) had lower standardized mortality ratios than might be expected due to chance. 

CONCLUSIONS:: Subarachnoid hemorrhage patients admitted to ICU in Australia and New Zealand have a high mortality rate. Year of admission beyond 2003 did not impact risk-adjusted in-hospital mortality. Significant variability was noted between institutions. This implies an urgent need to systematically evaluate many aspects of the critical care provided to this patient group.

Original languageEnglish
Pages (from-to)e138-e145
Number of pages8
JournalCritical Care Medicine
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2017

Cite this

Udy, A. A., Vladic, C., Saxby, E. R., Cohen, J., Delaney, A., Flower, O., ... Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (2017). Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand: A multicenter cohort analysis of in-hospital mortality over 15 Years. Critical Care Medicine, 45(2), e138-e145. https://doi.org/10.1097/CCM.0000000000002059
Udy, Andrew A. ; Vladic, Chelsey ; Saxby, Edward Robert ; Cohen, Jeremy ; Delaney, Anthony ; Flower, Oliver ; Anstey, Matthew ; Bellomo, Rinaldo ; Cooper, David James ; Pilcher, David V. ; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation. / Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand : A multicenter cohort analysis of in-hospital mortality over 15 Years. In: Critical Care Medicine. 2017 ; Vol. 45, No. 2. pp. e138-e145.
@article{392b821bfdd64f929253f1fb95552162,
title = "Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand: A multicenter cohort analysis of in-hospital mortality over 15 Years",
abstract = "OBJECTIVE:: The primary aim of this study was to describe in-hospital mortality in subarachnoid hemorrhage patients requiring ICU admission. Secondary aims were to identify clinical characteristics associated with inferior outcomes, to compare subarachnoid hemorrhage mortality with other neurological diagnoses, and to explore the variability in subarachnoid hemorrhage standardized mortality ratios. DESIGN:: Multicenter, binational, retrospective cohort study. SETTING:: Data were extracted from the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. PATIENTS:: All available records for the period January 2000 to June 2015. INTERVENTIONS:: Nil. MEASUREMENTS AND MAIN RESULTS:: A total of 11,327 subarachnoid hemorrhage patients were identified in the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. The overall case fatality rate was 29.2{\%}, which declined from 35.4{\%} in 2000 to 27.2{\%} in 2015 (p = 0.01). Older age, nonoperative admission, mechanical ventilation, higher Acute Physiology and Chronic Health Evaluation III scores, lower Glasgow Coma Scale, and admission prior to 2004 were all associated with lower hospital survival in multivariable analysis (p < 0.05). In comparison with other neurological diagnoses, subarachnoid hemorrhage patients had significantly greater risk-adjusted in-hospital mortality (odds ratio, 1.89 [95{\%} CI, 1.79–2.00]). Utilizing data from the 5 most recent complete years (2010–2014), three sites had higher and four (including the two largest centers) had lower standardized mortality ratios than might be expected due to chance. CONCLUSIONS:: Subarachnoid hemorrhage patients admitted to ICU in Australia and New Zealand have a high mortality rate. Year of admission beyond 2003 did not impact risk-adjusted in-hospital mortality. Significant variability was noted between institutions. This implies an urgent need to systematically evaluate many aspects of the critical care provided to this patient group.",
author = "Udy, {Andrew A.} and Chelsey Vladic and Saxby, {Edward Robert} and Jeremy Cohen and Anthony Delaney and Oliver Flower and Matthew Anstey and Rinaldo Bellomo and Cooper, {David James} and Pilcher, {David V.} and {Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation}",
year = "2017",
month = "2",
doi = "10.1097/CCM.0000000000002059",
language = "English",
volume = "45",
pages = "e138--e145",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

Udy, AA, Vladic, C, Saxby, ER, Cohen, J, Delaney, A, Flower, O, Anstey, M, Bellomo, R, Cooper, DJ, Pilcher, DV & Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation 2017, 'Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand: A multicenter cohort analysis of in-hospital mortality over 15 Years', Critical Care Medicine, vol. 45, no. 2, pp. e138-e145. https://doi.org/10.1097/CCM.0000000000002059

Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand : A multicenter cohort analysis of in-hospital mortality over 15 Years. / Udy, Andrew A.; Vladic, Chelsey; Saxby, Edward Robert; Cohen, Jeremy; Delaney, Anthony; Flower, Oliver; Anstey, Matthew; Bellomo, Rinaldo; Cooper, David James; Pilcher, David V.; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation.

In: Critical Care Medicine, Vol. 45, No. 2, 02.2017, p. e138-e145.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Subarachnoid hemorrhage patients admitted to intensive care in Australia and New Zealand

T2 - A multicenter cohort analysis of in-hospital mortality over 15 Years

AU - Udy, Andrew A.

AU - Vladic, Chelsey

AU - Saxby, Edward Robert

AU - Cohen, Jeremy

AU - Delaney, Anthony

AU - Flower, Oliver

AU - Anstey, Matthew

AU - Bellomo, Rinaldo

AU - Cooper, David James

AU - Pilcher, David V.

AU - Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation

PY - 2017/2

Y1 - 2017/2

N2 - OBJECTIVE:: The primary aim of this study was to describe in-hospital mortality in subarachnoid hemorrhage patients requiring ICU admission. Secondary aims were to identify clinical characteristics associated with inferior outcomes, to compare subarachnoid hemorrhage mortality with other neurological diagnoses, and to explore the variability in subarachnoid hemorrhage standardized mortality ratios. DESIGN:: Multicenter, binational, retrospective cohort study. SETTING:: Data were extracted from the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. PATIENTS:: All available records for the period January 2000 to June 2015. INTERVENTIONS:: Nil. MEASUREMENTS AND MAIN RESULTS:: A total of 11,327 subarachnoid hemorrhage patients were identified in the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. The overall case fatality rate was 29.2%, which declined from 35.4% in 2000 to 27.2% in 2015 (p = 0.01). Older age, nonoperative admission, mechanical ventilation, higher Acute Physiology and Chronic Health Evaluation III scores, lower Glasgow Coma Scale, and admission prior to 2004 were all associated with lower hospital survival in multivariable analysis (p < 0.05). In comparison with other neurological diagnoses, subarachnoid hemorrhage patients had significantly greater risk-adjusted in-hospital mortality (odds ratio, 1.89 [95% CI, 1.79–2.00]). Utilizing data from the 5 most recent complete years (2010–2014), three sites had higher and four (including the two largest centers) had lower standardized mortality ratios than might be expected due to chance. CONCLUSIONS:: Subarachnoid hemorrhage patients admitted to ICU in Australia and New Zealand have a high mortality rate. Year of admission beyond 2003 did not impact risk-adjusted in-hospital mortality. Significant variability was noted between institutions. This implies an urgent need to systematically evaluate many aspects of the critical care provided to this patient group.

AB - OBJECTIVE:: The primary aim of this study was to describe in-hospital mortality in subarachnoid hemorrhage patients requiring ICU admission. Secondary aims were to identify clinical characteristics associated with inferior outcomes, to compare subarachnoid hemorrhage mortality with other neurological diagnoses, and to explore the variability in subarachnoid hemorrhage standardized mortality ratios. DESIGN:: Multicenter, binational, retrospective cohort study. SETTING:: Data were extracted from the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. PATIENTS:: All available records for the period January 2000 to June 2015. INTERVENTIONS:: Nil. MEASUREMENTS AND MAIN RESULTS:: A total of 11,327 subarachnoid hemorrhage patients were identified in the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. The overall case fatality rate was 29.2%, which declined from 35.4% in 2000 to 27.2% in 2015 (p = 0.01). Older age, nonoperative admission, mechanical ventilation, higher Acute Physiology and Chronic Health Evaluation III scores, lower Glasgow Coma Scale, and admission prior to 2004 were all associated with lower hospital survival in multivariable analysis (p < 0.05). In comparison with other neurological diagnoses, subarachnoid hemorrhage patients had significantly greater risk-adjusted in-hospital mortality (odds ratio, 1.89 [95% CI, 1.79–2.00]). Utilizing data from the 5 most recent complete years (2010–2014), three sites had higher and four (including the two largest centers) had lower standardized mortality ratios than might be expected due to chance. CONCLUSIONS:: Subarachnoid hemorrhage patients admitted to ICU in Australia and New Zealand have a high mortality rate. Year of admission beyond 2003 did not impact risk-adjusted in-hospital mortality. Significant variability was noted between institutions. This implies an urgent need to systematically evaluate many aspects of the critical care provided to this patient group.

UR - http://www.scopus.com/inward/record.url?scp=84991478628&partnerID=8YFLogxK

U2 - 10.1097/CCM.0000000000002059

DO - 10.1097/CCM.0000000000002059

M3 - Article

VL - 45

SP - e138-e145

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 2

ER -