Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Jason Mackenzie, Lotti Tajouri, Attila Szvetko, Verena Weth, Julie Moreau, Judith M. Greer, Peter A. Csurhes, Michael P. Pender, Lyn R. Griffiths

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To examine a polymorphism within the 3′ untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population. Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/- 5 years) were included in the study. The LIF 3′ UTR StuI polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence. Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3′ UTR StuI polymorphism. Conclusion: The results indicate that the LIF 3′ UTR StuI polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility.

Original languageEnglish
Pages (from-to)62-64
Number of pages3
JournalJournal of the Neurological Sciences
Volume280
Issue number1-2
DOIs
Publication statusPublished - 15 May 2009
Externally publishedYes

Keywords

  • Australia
  • Leukemia inhibitory factor
  • Multiple sclerosis
  • Polymorphism
  • Restriction fragment length polymorphism
  • Susceptibility

Cite this

Mackenzie, J., Tajouri, L., Szvetko, A., Weth, V., Moreau, J., Greer, J. M., Csurhes, P. A., Pender, M. P., & Griffiths, L. R. (2009). Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. Journal of the Neurological Sciences, 280(1-2), 62-64. https://doi.org/10.1016/j.jns.2009.01.026