Studies on the effects prenatal immune activation on postnatal behavior: Models of developmental origins of schizophrenia

Udani Ratnayake, Rachel Anne Hill

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

Human epidemiological studies have indicated an association between infection during pregnancy and an increased risk of neurodevelopmental disorders such as schizophrenia in offspring. As infections arising from various causes have a similar debilitating effect in later life, it is thought that the maternal response, common to most infections, may be the critical factor altering fetal brain development. In this chapter, we discuss various animal models of prenatal exposure to an infection, that have aimed to cause neurobiological, pharmacological and behavioral abnormalities in offspring comparable to those seen in schizophrenic patients. We propose that one such model, the prenatal treatment with the viral mimetic, polyriboinosinic-polyribocytidylic acid (Poly I:C) successfully demonstrates critical features of the human disorder. Therefore, this model is ideal to further investigate the neurodevelopmental basis of schizophrenia and, importantly, may provide a useful tool for testing treatment strategies.

Original languageEnglish
Title of host publicationPrenatal and Postnatal Determinants of Development
EditorsDavid W. Walker
Place of PublicationNew York NY USA
PublisherHumana Press
Pages263-278
Number of pages16
Volume109
ISBN (Electronic)9781493930142
ISBN (Print)97817493930135
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

Publication series

NameNeuromethods
PublisherHumana Press
Volume109
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Animal model
  • Behavior
  • Poly I:C
  • Prenatal immune activation
  • Schizophrenia
  • Symptoms

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