Studies on accessory cells in the adoptive antibody response to sheep erythrocytes in mice

CBA mice irradiated 3 days prior to injection of syngeneic nonadherent spleen cells and high numbers of SRBC contained approximately ten times more splenic direct plaque forming cells than mice irradiated immediately prior to transfer. This was not true of C57B1 mice. Increased responses in the CBA mice were shown to be dependent upon accessory cells (A cells). The results suggest that A cells are affected differently by irradiation in different strains of mice.