Studies on accessory cells in the adoptive antibody response to sheep erythrocytes in mice

R. L. Coppel, G. F. Mitchell

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CBA mice irradiated 3 days prior to injection of syngeneic nonadherent spleen cells and high numbers of SRBC contained approximately ten times more splenic direct plaque forming cells than mice irradiated immediately prior to transfer. This was not true of C57B1 mice. Increased responses in the CBA mice were shown to be dependent upon accessory cells (A cells). The results suggest that A cells are affected differently by irradiation in different strains of mice.

Original languageEnglish
Pages (from-to)411-423
Number of pages13
JournalCellular Immunology
Issue number2
Publication statusPublished - 1 Jan 1975
Externally publishedYes

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