Abstract
Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates (NHPs) measles virus (MV) infects and depletes pre-existing memory lymphocytes, causing immune amnesia. A measles outbreak in the Dutch Orthodox Protestant community provided a unique opportunity to study the pathogenesis of measles immune suppression in unvaccinated children. In peripheral blood mononuclear cells (PBMC) of prodromal measles patients, we detected MV-infected memory CD4 + and CD8 + T cells and naive and memory B cells at similar levels as those observed in NHPs. In paired PBMC collected before and after measles we found reduced frequencies of circulating memory B cells and increased frequencies of regulatory T cells and transitional B cells after measles. These data support our immune amnesia hypothesis and offer an explanation for the previously observed long-term effects of measles on host resistance. This study emphasises the importance of maintaining high measles vaccination coverage.
| Original language | English |
|---|---|
| Article number | 4944 |
| Number of pages | 10 |
| Journal | Nature Communications |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Dec 2018 |
Cite this
}
Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands. / Laksono, Brigitta M.; de Vries, Rory D.; Verburgh, R. Joyce; Visser, Eline G.; de Jong, Alwin; Fraaij, Pieter L.A.; Ruijs, Wilhemina L.M.; Nieuwenhuijse, David F.; van den Ham, Henk Jan; Koopmans, Marion P.G.; van Zelm, Menno C.; Osterhaus, Albert D.M.E.; de Swart, Rik L.
In: Nature Communications, Vol. 9, No. 1, 4944, 01.12.2018.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands
AU - Laksono, Brigitta M.
AU - de Vries, Rory D.
AU - Verburgh, R. Joyce
AU - Visser, Eline G.
AU - de Jong, Alwin
AU - Fraaij, Pieter L.A.
AU - Ruijs, Wilhemina L.M.
AU - Nieuwenhuijse, David F.
AU - van den Ham, Henk Jan
AU - Koopmans, Marion P.G.
AU - van Zelm, Menno C.
AU - Osterhaus, Albert D.M.E.
AU - de Swart, Rik L.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates (NHPs) measles virus (MV) infects and depletes pre-existing memory lymphocytes, causing immune amnesia. A measles outbreak in the Dutch Orthodox Protestant community provided a unique opportunity to study the pathogenesis of measles immune suppression in unvaccinated children. In peripheral blood mononuclear cells (PBMC) of prodromal measles patients, we detected MV-infected memory CD4 + and CD8 + T cells and naive and memory B cells at similar levels as those observed in NHPs. In paired PBMC collected before and after measles we found reduced frequencies of circulating memory B cells and increased frequencies of regulatory T cells and transitional B cells after measles. These data support our immune amnesia hypothesis and offer an explanation for the previously observed long-term effects of measles on host resistance. This study emphasises the importance of maintaining high measles vaccination coverage.
AB - Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates (NHPs) measles virus (MV) infects and depletes pre-existing memory lymphocytes, causing immune amnesia. A measles outbreak in the Dutch Orthodox Protestant community provided a unique opportunity to study the pathogenesis of measles immune suppression in unvaccinated children. In peripheral blood mononuclear cells (PBMC) of prodromal measles patients, we detected MV-infected memory CD4 + and CD8 + T cells and naive and memory B cells at similar levels as those observed in NHPs. In paired PBMC collected before and after measles we found reduced frequencies of circulating memory B cells and increased frequencies of regulatory T cells and transitional B cells after measles. These data support our immune amnesia hypothesis and offer an explanation for the previously observed long-term effects of measles on host resistance. This study emphasises the importance of maintaining high measles vaccination coverage.
UR - http://www.scopus.com/inward/record.url?scp=85057080454&partnerID=8YFLogxK
U2 - 10.1038/s41467-018-07515-0
DO - 10.1038/s41467-018-07515-0
M3 - Article
VL - 9
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 4944
ER -