Abstract
Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.
Original language | English |
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Pages (from-to) | 739-743 |
Number of pages | 5 |
Journal | Acta Crystallographica Section F: Structural Biology Communications |
Volume | 67 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2011 |
Externally published | Yes |
Keywords
- CCP
- complement regulator
- CrrY
- rat