Structures of the rat complement regulator CrrY

Pietro Roversi, Steven Johnson, Joseph J.E. Caesar, Florence McLean, Kirstin J. Leath, Stefanos A Tsiftsoglou, B. Paul Morgan, Claire L. Harris, Robert B. Sim, Susan M. Lea

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Abstract

Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalActa Crystallographica. Section F: Structural Biology Communications
Volume67
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Keywords

  • CCP
  • complement regulator
  • CrrY
  • rat

Cite this

Roversi, P., Johnson, S., Caesar, J. J. E., McLean, F., Leath, K. J., Tsiftsoglou, S. A., Morgan, B. P., Harris, C. L., Sim, R. B., & Lea, S. M. (2011). Structures of the rat complement regulator CrrY. Acta Crystallographica. Section F: Structural Biology Communications, 67(7), 739-743. https://doi.org/10.1107/S1744309111016551