Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides

Anthony J. Mason, Bronwyn A. Evans, David R. Cox, John Shine, Robert I. Richards

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234 Citations (Scopus)

Abstract

The glandular kallikrein gene family comprises 25-30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides. In the mouse all the members of this family are closely linked on chromosome 7. The 9.5-kilobase nucleotide sequence of a mouse genomic clone contains one complete kallikrein gene (mGK-1), which is expressed in the male mouse submaxillary gland, and the 3′ end of another (mGK-2). Differences in the coding potential of these genes and the amino acid sequences of other known kallikreins seem to be functionally related to the substrate specificity of the different enzymes.

Original languageEnglish
Pages (from-to)300-307
Number of pages8
JournalNature
Volume303
Issue number5915
DOIs
Publication statusPublished - 1 Dec 1983
Externally publishedYes

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