Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products

Dennis X. Hu, David M. Withall, Gregory L. Challis, Regan J. Thomson

Research output: Contribution to journalReview ArticleOtherpeer-review

84 Citations (Scopus)


The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural products that have likely been known to man since antiquity. In more recent times, these alkaloids have been discovered to span a wide range of chemical structures that possess a number of interesting biological activities. This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, research toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively reviewed. Finally, the current, evidence-based understanding of the various biosynthetic pathways employed by bacteria to produce prodiginine alkaloids is summarized.

Original languageEnglish
Pages (from-to)7818-7853
Number of pages36
JournalChemical Reviews
Issue number14
Publication statusPublished - 27 Jul 2016
Externally publishedYes

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