TY - JOUR
T1 - Structure, biological functions and applications of the AB5 toxins
AU - Beddoe, Travis Clarke
AU - Paton, Adrienne Webster
AU - Le Nours, Jerome
AU - Rossjohn, Jamie
AU - Paton, James C
PY - 2010
Y1 - 2010
N2 - AB(5) toxins are important virulence factors for several major bacterial pathogens, including Bordetella pertussis, Vibrio cholerae, Shigella dysenteriae and at least two distinct pathotypes of Escherichia coli. The AB(5) toxins are so named because they comprise a catalytic A-subunit, which is responsible for disruption of essential host functions, and a pentameric B-subunit that binds to specific glycan receptors on the target cell surface. The molecular mechanisms by which the AB(5) toxins cause disease have been largely unravelled, including recent insights into a novel AB(5) toxin family, subtilase cytotoxin (SubAB). Furthermore, AB(5) toxins have become a valuable tool for studying fundamental cellular functions, and are now being investigated for potential applications in the clinical treatment of human diseases.
AB - AB(5) toxins are important virulence factors for several major bacterial pathogens, including Bordetella pertussis, Vibrio cholerae, Shigella dysenteriae and at least two distinct pathotypes of Escherichia coli. The AB(5) toxins are so named because they comprise a catalytic A-subunit, which is responsible for disruption of essential host functions, and a pentameric B-subunit that binds to specific glycan receptors on the target cell surface. The molecular mechanisms by which the AB(5) toxins cause disease have been largely unravelled, including recent insights into a novel AB(5) toxin family, subtilase cytotoxin (SubAB). Furthermore, AB(5) toxins have become a valuable tool for studying fundamental cellular functions, and are now being investigated for potential applications in the clinical treatment of human diseases.
UR - http://www.ncbi.nlm.nih.gov/pubmed/20202851
U2 - 10.1016/j.tibs.2010.02.003
DO - 10.1016/j.tibs.2010.02.003
M3 - Article
SN - 0968-0004
VL - 35
SP - 411
EP - 418
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 7
ER -