Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

Hai-Jing Zhong, Bo Ra Lee, Joshua William Boyle, Wanhe Wang, Dik-Lung Edmond Ma, Philip Wai Hong Chan, Chung-Hang Duncan Leung

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.

Original languageEnglish
Pages (from-to)5788-5791
Number of pages4
JournalChemical Communications
Volume52
Issue number34
DOIs
Publication statusPublished - 30 Apr 2016

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