Abstract
The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
Original language | English |
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Pages (from-to) | 5788-5791 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 52 |
Issue number | 34 |
DOIs | |
Publication status | Published - 30 Apr 2016 |