Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli

J. F. Garcia-Bustos; N. Pezzi; E. Mendez

doi:10.1128/AAC.27.5.791

Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli

J. F. Garcia-Bustos, N. Pezzi, E. Mendez

Research output: Contribution to journal › Article › Research › peer-review

57 Citations (Scopus)

Abstract

Microcin 7 is a small peptide produced and excreted to the culture medium by stationary-phase Escherichia coli cells harboring the pMccC7 plasmid (formerly named pRYC7). This peptide inhibited the growth of the enterobacteria phylogenetically closer to E. coli, apparently by blocking protein biosynthesis. The molecule was degraded with trypsin, and the resulting fragments were purified and sequenced. The results show that microcin 7 is a linear heptapeptide blocked at both ends.

Original language	English
Pages (from-to)	791-797
Number of pages	7
Journal	Antimicrobial Agents and Chemotherapy
Volume	27
Issue number	5
DOIs	https://doi.org/10.1128/AAC.27.5.791
Publication status	Published - 1 Jan 1985
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1128/AAC.27.5.791

Cite this

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abstract = "Microcin 7 is a small peptide produced and excreted to the culture medium by stationary-phase Escherichia coli cells harboring the pMccC7 plasmid (formerly named pRYC7). This peptide inhibited the growth of the enterobacteria phylogenetically closer to E. coli, apparently by blocking protein biosynthesis. The molecule was degraded with trypsin, and the resulting fragments were purified and sequenced. The results show that microcin 7 is a linear heptapeptide blocked at both ends.",

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AU - Pezzi, N.

AU - Mendez, E.

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AB - Microcin 7 is a small peptide produced and excreted to the culture medium by stationary-phase Escherichia coli cells harboring the pMccC7 plasmid (formerly named pRYC7). This peptide inhibited the growth of the enterobacteria phylogenetically closer to E. coli, apparently by blocking protein biosynthesis. The molecule was degraded with trypsin, and the resulting fragments were purified and sequenced. The results show that microcin 7 is a linear heptapeptide blocked at both ends.

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli

Abstract

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