Projects per year
Abstract
Peptides typically display high potency and target selectivity, making them valuable leads in the development of new therapeutics. Indeed, many peptides have made the transition to clinical use, including cyclosporine (cyclosporin A) [1, 2], gonadotropin-releasing hormone (also known as luteinizing-hormone releasing hormone) agonists and antagonists [3, 4], somatostatin analogs [3, 4], exenatide [5], ziconotide [6], andglatiramer acetate [7], to name just a few. Nonetheless, converting lead peptides to drugs represents a considerable challenge. Many peptides lack oral bioavailability as a consequence of their susceptibility to proteolysis in the gut, inefficient transport across the intestinal wall, proteolytic degradation in the bloodstream, and rapid clearance by the kidney.
Original language | English |
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Title of host publication | Amino Acids, Peptides and Proteins in Organic Chemistry |
Subtitle of host publication | Analysis and Function of Amino Acids and Peptides |
Editors | Andrew B. Hughes |
Place of Publication | Weinheim Germany |
Publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
Pages | 155-166 |
Number of pages | 12 |
Volume | 5 |
ISBN (Electronic) | 9783527631858 |
ISBN (Print) | 9783527321049 |
DOIs | |
Publication status | Published - 28 Nov 2011 |
Keywords
- Conformation
- Energy calculation
- N-methylation
- Nuclear magnetic resonance
- Peptide
- X-ray crystallography
Projects
- 1 Finished
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NHMRC Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
1/01/09 → 31/12/18
Project: Research