Structural relationships among chloramphenicol-resistance plasmids of Staphylococcus aureus

M. T. Gillespie, R. A. Skurray

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Twelve different chloramphenicol-resistance (Cmr) plasmids detected in Staphylococcus aureus strains isolated between 1952 and 1981 were characterized by restriction endonuclease, DNA hybridization and heteroduplex analyses. These studies revealed three families of Cmr plasmids which were distinguished by their chloramphenicol acetyltransferase sequences; the prototype plasmids of the families were pC221, pC223 and pC194. The cat and replication (rep) genes of the plasmid pC221 were highly conserved in other pC221 family members and were related to their homologs in the pC223 family plasmids; however, the cat and rep genes of the pC194 family plasmids were distinct.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalFEMS Microbiology Letters
Issue number2-3
Publication statusPublished - 15 Jun 1988


  • Antibiotic-resistance
  • Chloramphenicol
  • R plasmid
  • Staphylococcus aureus

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