Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data

Brian P Hallahan, John W Newell, Jair Constante Soares, Paulo Brambilla, Stephen M Strakowski, David E Fleck, Tuula Kiesepp, Lori L Altshuler, Alex Fornito, Gin S Malhi, Andrew M McIntosh, Deborah A Yurgelun-Todd, Kevin S Labar, Verinder K Sharma, Glenda M MacQueen, Robin MacGregor Murray, Colm D McDonald

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There is substantial inconsistency in results of brain structural magnetic resonance imaging studies in adult bipolar disorder. This is likely consequent upon limited statistical power of studies together with their clinical and methodological heterogeneity. The current study was undertaken to perform an international collaborative mega-analysis of regional volumetric measurements of individual patient and healthy subject data, to optimize statistical power, detect case-control differences, assess the association of psychotropic medication usage with brain structural variation, and detect other possible sources of heterogeneity.
Original languageEnglish
Pages (from-to)326-335
Number of pages10
JournalBiological Psychiatry
Issue number4
Publication statusPublished - 15 Feb 2011
Externally publishedYes


  • amygdala
  • bipolar disorder
  • hippocampus
  • lateral ventricles
  • lithium
  • mega-analysis

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