Abstract
There is substantial inconsistency in results of brain structural magnetic resonance imaging studies in adult bipolar disorder. This is likely consequent upon limited statistical power of studies together with their clinical and methodological heterogeneity. The current study was undertaken to perform an international collaborative mega-analysis of regional volumetric measurements of individual patient and healthy subject data, to optimize statistical power, detect case-control differences, assess the association of psychotropic medication usage with brain structural variation, and detect other possible sources of heterogeneity.
Original language | English |
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Pages (from-to) | 326-335 |
Number of pages | 10 |
Journal | Biological Psychiatry |
Volume | 69 |
Issue number | 4 |
DOIs | |
Publication status | Published - 15 Feb 2011 |
Externally published | Yes |
Keywords
- amygdala
- bipolar disorder
- hippocampus
- lateral ventricles
- lithium
- mega-analysis