Structural glycobiology of antibody recognition in xenotransplantation and cancer immunotherapy

Mark James Agostino, William Farrugia, Mauro Sergio Sandrin, Andrew M Scott, Elizabeth Yuriev, Paul Allen Ramsland

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

5 Citations (Scopus)

Abstract

In this chapter, we discuss the structural glycobiology of the key antibody?carbohydrate interactions important in xenotransplantation and cancer immunotherapy. Progress in both fields is reliant on further mechanistic knowledge of the underlying complex biosynthetic pathways and the structural basis for antibody recognition of isolated and cellular forms of the target carbohydrates.
Original languageEnglish
Title of host publicationAnticarbohydrate antibodies
EditorsPaul Kosma, Sven Muller-Loennies
Place of PublicationNew York USA
PublisherSpringer
Pages203 - 228
Number of pages26
ISBN (Print)9783709108697
DOIs
Publication statusPublished - 2012

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