Structural examination of 6-methylsulphonylphenanthro-[9,10-C]-furan-1(3H)-one-a rofecoxib degradation product

Pamela Mary Dean

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Abstract

In the attempt to discover a new polymorph of rofecoxib (VioxxA?), an unexpected product resulted. The product was characterised by chemical composition, thermal behaviour and structure and found to be 6-methylsulphonylphenanthro-[9,10-C] furan-1(3H)-one, a photo-cyclization degradation product of rofecoxib. This is a significant finding because it indicates that without appropriate control of the recrystallisation procedures, the structural integrity of rofecoxib may be seriously compromised.
Original languageEnglish
Pages (from-to)369 - 378
Number of pages10
JournalPharmaceuticals
Volume3
Issue number2
DOIs
Publication statusPublished - 2010

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