Structural examination of 6-methylsulphonylphenanthro-[9,10-C]-furan-1(3H)-one-a rofecoxib degradation product

Pamela Mary Dean

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


In the attempt to discover a new polymorph of rofecoxib (VioxxA?), an unexpected product resulted. The product was characterised by chemical composition, thermal behaviour and structure and found to be 6-methylsulphonylphenanthro-[9,10-C] furan-1(3H)-one, a photo-cyclization degradation product of rofecoxib. This is a significant finding because it indicates that without appropriate control of the recrystallisation procedures, the structural integrity of rofecoxib may be seriously compromised.
Original languageEnglish
Pages (from-to)369-378
Number of pages10
Issue number2
Publication statusPublished - 2010

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