Abstract
In the attempt to discover a new polymorph of rofecoxib (VioxxA?), an unexpected product resulted. The product was characterised by chemical composition, thermal behaviour and structure and found to be 6-methylsulphonylphenanthro-[9,10-C] furan-1(3H)-one, a photo-cyclization degradation product of rofecoxib. This is a significant finding because it indicates that without appropriate control of the recrystallisation procedures, the structural integrity of rofecoxib may be seriously compromised.
| Original language | English |
|---|---|
| Pages (from-to) | 369 - 378 |
| Number of pages | 10 |
| Journal | Pharmaceuticals |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2010 |