Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain; Florence Larrous; Stephen M. Rawlinson; Jingyu Zhan; Ashish Sethi; Youssef Ibrahim; Maria Aloi; Kim G. Lieu; Yee Foong Mok; Michael D.W. Griffin; Naoto Ito; Toyoyuki Ose; Hervé Bourhy; Gregory W. Moseley; Paul R. Gooley

doi:10.1016/j.celrep.2019.10.020

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M. Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G. Lieu, Yee Foong Mok, Michael D.W. Griffin, Naoto Ito, Toyoyuki Ose, Hervé Bourhy, Gregory W. Moseley, Paul R. Gooley

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

Hossain et al. explore the binding surface of the multifunctional P-protein of rabies virus for STAT1, a protein that is essential for establishing the antiviral response of infected cells. They identify a complex interface comprising several distinct sites and demonstrate that targeted modifications of these can significantly attenuate pathogenic virus.

Original language	English
Pages (from-to)	1934-1945
Number of pages	12
Journal	Cell Reports
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2019.10.020
Publication status	Published - 12 Nov 2019

Keywords

immune evasion
innate immunity
interferon
interferon antagonist
lyssavirus
nuclear magnetic resonance
P protein
rabies
STAT1
virus

Access to Document

10.1016/j.celrep.2019.10.020

299197366-oaFinal published version, 3.12 MB

Cite this

@article{821b9fb0c2a1441ca1c0c68a975b1923,

title = "Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface",

abstract = "Hossain et al. explore the binding surface of the multifunctional P-protein of rabies virus for STAT1, a protein that is essential for establishing the antiviral response of infected cells. They identify a complex interface comprising several distinct sites and demonstrate that targeted modifications of these can significantly attenuate pathogenic virus.",

keywords = "immune evasion, innate immunity, interferon, interferon antagonist, lyssavirus, nuclear magnetic resonance, P protein, rabies, STAT1, virus",

author = "Hossain, {Md Alamgir} and Florence Larrous and Rawlinson, {Stephen M.} and Jingyu Zhan and Ashish Sethi and Youssef Ibrahim and Maria Aloi and Lieu, {Kim G.} and Mok, {Yee Foong} and Griffin, {Michael D.W.} and Naoto Ito and Toyoyuki Ose and Herv{\'e} Bourhy and Moseley, {Gregory W.} and Gooley, {Paul R.}",

year = "2019",

month = nov,

day = "12",

doi = "10.1016/j.celrep.2019.10.020",

language = "English",

volume = "29",

pages = "1934--1945",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier",

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}

TY - JOUR

T1 - Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

AU - Hossain, Md Alamgir

AU - Larrous, Florence

AU - Rawlinson, Stephen M.

AU - Zhan, Jingyu

AU - Sethi, Ashish

AU - Ibrahim, Youssef

AU - Aloi, Maria

AU - Lieu, Kim G.

AU - Mok, Yee Foong

AU - Griffin, Michael D.W.

AU - Ito, Naoto

AU - Ose, Toyoyuki

AU - Bourhy, Hervé

AU - Moseley, Gregory W.

AU - Gooley, Paul R.

PY - 2019/11/12

Y1 - 2019/11/12

N2 - Hossain et al. explore the binding surface of the multifunctional P-protein of rabies virus for STAT1, a protein that is essential for establishing the antiviral response of infected cells. They identify a complex interface comprising several distinct sites and demonstrate that targeted modifications of these can significantly attenuate pathogenic virus.

AB - Hossain et al. explore the binding surface of the multifunctional P-protein of rabies virus for STAT1, a protein that is essential for establishing the antiviral response of infected cells. They identify a complex interface comprising several distinct sites and demonstrate that targeted modifications of these can significantly attenuate pathogenic virus.

KW - immune evasion

KW - innate immunity

KW - interferon

KW - interferon antagonist

KW - lyssavirus

KW - nuclear magnetic resonance

KW - P protein

KW - rabies

KW - STAT1

KW - virus

UR - http://www.scopus.com/inward/record.url?scp=85074650168&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.10.020

DO - 10.1016/j.celrep.2019.10.020

M3 - Article

C2 - 31722208

AN - SCOPUS:85074650168

VL - 29

SP - 1934

EP - 1945

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 7

ER -

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Abstract

Keywords

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Other files and links

Viral hijacking of the nucleolar DNA-damage response machinery: novel mechanisms to regulate host cell biology

Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis

Viral targeting of STAT proteins: roles in disease

Monash Micro Imaging

Cite this

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Abstract

Keywords

Access to Document

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Projects

Viral hijacking of the nucleolar DNA-damage response machinery: novel mechanisms to regulate host cell biology

Defining the Molecular Mechanisms of Lyssavirus Replication and Immune Evasion: the P protein Axis

Viral targeting of STAT proteins: roles in disease

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Monash Micro Imaging

Cite this