Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M. Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G. Lieu, Yee Foong Mok, Michael D.W. Griffin, Naoto Ito, Toyoyuki Ose, Hervé Bourhy, Gregory W. Moseley, Paul R. Gooley

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10 Citations (Scopus)

Abstract

Hossain et al. explore the binding surface of the multifunctional P-protein of rabies virus for STAT1, a protein that is essential for establishing the antiviral response of infected cells. They identify a complex interface comprising several distinct sites and demonstrate that targeted modifications of these can significantly attenuate pathogenic virus.

Original languageEnglish
Pages (from-to)1934-1945
Number of pages12
JournalCell Reports
Volume29
Issue number7
DOIs
Publication statusPublished - 12 Nov 2019

Keywords

  • immune evasion
  • innate immunity
  • interferon
  • interferon antagonist
  • lyssavirus
  • nuclear magnetic resonance
  • P protein
  • rabies
  • STAT1
  • virus

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