TY - JOUR
T1 - Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12
AU - Sterjovski, Jasminka
AU - Churchill, Melissa
AU - Ellett, Anne
AU - Wesselingh, Steven L
AU - Ramsland, Paul Allen
AU - Gorry, Paul R
PY - 2012
Y1 - 2012
N2 - Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of
neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their
b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope
AB - Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of
neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their
b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope
U2 - 10.1016/j.virol.2012.06.024
DO - 10.1016/j.virol.2012.06.024
M3 - Article
SN - 0042-6822
VL - 432
SP - 394
EP - 404
JO - Virology
JF - Virology
IS - 2
ER -
