Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12

Jasminka Sterjovski, Melissa Churchill, Anne Ellett, Steven L Wesselingh, Paul Allen Ramsland, Paul R Gorry

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope
Original languageEnglish
Pages (from-to)394 - 404
Number of pages11
Issue number2
Publication statusPublished - 2012

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