Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12

Jasminka Sterjovski, Melissa Churchill, Anne Ellett, Steven L Wesselingh, Paul Allen Ramsland, Paul R Gorry

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope
Original languageEnglish
Pages (from-to)394 - 404
Number of pages11
JournalVirology
Volume432
Issue number2
DOIs
Publication statusPublished - 2012

Cite this

@article{fbf13eeb3eb646a1b5b6852117546fb8,
title = "Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12",
abstract = "Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope",
author = "Jasminka Sterjovski and Melissa Churchill and Anne Ellett and Wesselingh, {Steven L} and Ramsland, {Paul Allen} and Gorry, {Paul R}",
year = "2012",
doi = "10.1016/j.virol.2012.06.024",
language = "English",
volume = "432",
pages = "394 -- 404",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press",
number = "2",

}

Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12. / Sterjovski, Jasminka; Churchill, Melissa; Ellett, Anne; Wesselingh, Steven L; Ramsland, Paul Allen; Gorry, Paul R.

In: Virology, Vol. 432, No. 2, 2012, p. 394 - 404.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Structural elements of primary CCR5-using HIV-1 gp120 proteins influencing sensitivity and resistance to the broadly neutralizing monoclonal antibody b12

AU - Sterjovski, Jasminka

AU - Churchill, Melissa

AU - Ellett, Anne

AU - Wesselingh, Steven L

AU - Ramsland, Paul Allen

AU - Gorry, Paul R

PY - 2012

Y1 - 2012

N2 - Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope

AB - Structure-guided approaches to HIV-1 vaccine design depend on knowledge of thepresentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAbb12. Here,we characterized predicted three-dimensional structures of functionally diverse gp120 proteins in their b12-bound conformation, to better understand the gp120 determinants that expose or occlude the b12 epitope

U2 - 10.1016/j.virol.2012.06.024

DO - 10.1016/j.virol.2012.06.024

M3 - Article

VL - 432

SP - 394

EP - 404

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -