Structural biology: Torqueing about pores

James Whisstock; Michelle Anne Dunstone

doi:10.1038/nchembio.1341

Structural biology: Torqueing about pores

James Whisstock, Michelle Anne Dunstone

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Other

Abstract

Cryo-EM, crystallography, biochemical experiments and computational approaches have been used to study different intermediate states of the Aeromonas hydrophila toxin aerolysin en route to pore formation. These results reveal that an unexpected and marked rotation of the core aerolysin machinery is required to unleash the membrane-spanning regions.

Original language	English
Pages (from-to)	605 - 606
Number of pages	2
Journal	Nature Chemical Biology
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nchembio.1341
Publication status	Published - 2013

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10.1038/nchembio.1341

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Cite this

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title = "Structural biology: Torqueing about pores",

abstract = "Cryo-EM, crystallography, biochemical experiments and computational approaches have been used to study different intermediate states of the Aeromonas hydrophila toxin aerolysin en route to pore formation. These results reveal that an unexpected and marked rotation of the core aerolysin machinery is required to unleash the membrane-spanning regions.",

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