Structural biology: Torqueing about pores

Research output: Contribution to journalArticleOther

Abstract

Cryo-EM, crystallography, biochemical experiments and computational approaches have been used to study different intermediate states of the Aeromonas hydrophila toxin aerolysin en route to pore formation. These results reveal that an unexpected and marked rotation of the core aerolysin machinery is required to unleash the membrane-spanning regions.
Original languageEnglish
Pages (from-to)605 - 606
Number of pages2
JournalNature Chemical Biology
Volume9
Issue number10
DOIs
Publication statusPublished - 2013

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