Structural biology of the PCI-protein fold

Andrew M Ellisdon, Murray Stewart

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)


The PCI fold is based on a stack of alpha-helices topped with a winged-helix domain and is found in a range of proteins that form central parts of large complexes such as the proteasome lid, the COP9 signalosome, elongation factor eIF3, and the TREX-2 complex. Recent structural determinations have given intriguing insight into how these folds function both to facilitate the generation of larger proteinaceous assembles and also to interact functionally with nucleic acids.
Original languageEnglish
Pages (from-to)1 - 6
Number of pages6
Issue number4
Publication statusPublished - 2012

Cite this