Structural basis of efficacy-driven ligand selectivity at GPCRs

Alexander S. Powers, Vi Pham, Wessel A.C. Burger, Geoff Thompson, Yianni Laloudakis, Nick Barnes, Patrick M. Sexton, Steven M. Paul, Arthur Christopoulos, David M. Thal, Christian C. Felder, Celine Valant, Ron O. Dror

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

2 Active
5 Finished

7 results

Active

ARC Industrial Transformation Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery
Sexton, P., Rouiller, I., Wootten, D., van Oijen, A., Parker, M. W., Lucet, I., Griffin, M. D. W., Adams, D. J., Czabotar, P. E., Flocco, M., Han, S., Shepherd, R., Ciferri, C., Williams, P. A., Brown, D., Schreuder, H., Reedtz-Runge, S., Drinkwater, C., Howard, B. L., Betigeri, G., Pryor, E. & How, J.
Boehringer Ingelheim (Germany), AstraZeneca (United Kingdom)
23/03/21 → 22/03/26
Project: Research
Using protein structure and dynamics to facilitate drug discovery
Thal, D.
1/01/21 → 31/12/25
Project: Research
Finished

Discovering novel allosteric probes of muscarinic acetylcholine receptors
Valant, C., Scammells, P. & Christopoulos, A.
3/06/19 → 31/12/22
Project: Research
NHMRC Research Fellowship
Sexton, P.
1/01/19 → 31/12/23
Project: Research
Translating membrane proteins into therapeutics; from bedside to bench
Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.
1/01/19 → 31/12/23
Project: Research
Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors
Thal, D., Gooley, P. R. & Dror, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 30/09/22
Project: Research
Molecular insight into allosteric modulation of G protein-coupled receptors
Thal, D.
Australian Research Council (ARC)
1/01/17 → 31/12/19
Project: Research