Cutting carbons: The three-dimensional structure of polyneuridine aldehyde esterase (PNAE) gives insight into the enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids (see scheme). PNAE is a very substrate-specific serine esterase. It harbors the catalytic triad S87-D216-H244, and is a new member of the α/ β-fold hydrolase superfamily. Its novel function leads to the diversification of alkaloid structures.
- Enzyme catalysis
- Protein structures