Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1031 - 1039 |
| Number of pages | 9 |
| Journal | Journal of Biomechanics |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2011 |
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Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice. / Tovar-Lopez, Francisco Javier; Rosengarten, Gary; Khoshmanesh, Khashayar; Westein, Erik; Jackson, Shaun; Nesbitt, Warwick Scott; Mitchell, Arnan.
In: Journal of Biomechanics, Vol. 44, No. 6, 2011, p. 1031 - 1039.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice
AU - Tovar-Lopez, Francisco Javier
AU - Rosengarten, Gary
AU - Khoshmanesh, Khashayar
AU - Westein, Erik
AU - Jackson, Shaun
AU - Nesbitt, Warwick Scott
AU - Mitchell, Arnan
PY - 2011
Y1 - 2011
N2 - This paper presents a computational structural and hydrodynamic simulation of acute stenotic blood flow in the small bowel mesenteric vessels of mice. Using a homogeneous fluid at low Reynolds number (0.45) we investigated the relationship between the local hydrodynamic strain-rates and the severity of arteriolar stensosis. We conclude that the critical rates of blood flow acceleration and deceleration at sites of artificially induced stenosis (vessel side-wall compression or ligation) are a function of tissue elasticity. By implementing a structural simulation of arteriolar side wall compression, we present a mechanistic model that provides accurate simulations of stenosis in vivo and allows for predictions of the effects on local haemodynamics in the murine small bowel mesenteric thrombosis model. A? 2011 Elsevier Ltd.
AB - This paper presents a computational structural and hydrodynamic simulation of acute stenotic blood flow in the small bowel mesenteric vessels of mice. Using a homogeneous fluid at low Reynolds number (0.45) we investigated the relationship between the local hydrodynamic strain-rates and the severity of arteriolar stensosis. We conclude that the critical rates of blood flow acceleration and deceleration at sites of artificially induced stenosis (vessel side-wall compression or ligation) are a function of tissue elasticity. By implementing a structural simulation of arteriolar side wall compression, we present a mechanistic model that provides accurate simulations of stenosis in vivo and allows for predictions of the effects on local haemodynamics in the murine small bowel mesenteric thrombosis model. A? 2011 Elsevier Ltd.
UR - http://www.sciencedirect.com.ezproxy.lib.monash.edu.au/science/article/pii/S002192901100087X
U2 - 10.1016/j.jbiomech.2011.02.006
DO - 10.1016/j.jbiomech.2011.02.006
M3 - Article
VL - 44
SP - 1031
EP - 1039
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 6
ER -