Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

Francisco Javier Tovar-Lopez, Gary Rosengarten, Khashayar Khoshmanesh, Erik Westein, Shaun Jackson, Warwick Scott Nesbitt, Arnan Mitchell

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10 Citations (Scopus)

Abstract

This paper presents a computational structural and hydrodynamic simulation of acute stenotic blood flow in the small bowel mesenteric vessels of mice. Using a homogeneous fluid at low Reynolds number (0.45) we investigated the relationship between the local hydrodynamic strain-rates and the severity of arteriolar stensosis. We conclude that the critical rates of blood flow acceleration and deceleration at sites of artificially induced stenosis (vessel side-wall compression or ligation) are a function of tissue elasticity. By implementing a structural simulation of arteriolar side wall compression, we present a mechanistic model that provides accurate simulations of stenosis in vivo and allows for predictions of the effects on local haemodynamics in the murine small bowel mesenteric thrombosis model. A? 2011 Elsevier Ltd.
Original languageEnglish
Pages (from-to)1031 - 1039
Number of pages9
JournalJournal of Biomechanics
Volume44
Issue number6
DOIs
Publication statusPublished - 2011

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