Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease

Peter McColgan, Adeel Razi, Sarah Gregory, Kiran K. Seunarine, Alexandra Durr, Raymund A.C. Roos, Blair R. Leavitt, Rachael I. Scahill, Chris A. Clark, Doug R. Langbehn, Geraint Rees, Sarah J. Tabrizi, Track On-HD Investigators

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for connections in the default mode network (DMN) and basal ganglia in preHD. This study reveals specific connections in the DMN and basal ganglia that are associated with depressive symptoms in preHD. Hum Brain Mapp 38:2819–2829, 2017.

Original languageEnglish
Pages (from-to)2819-2829
Number of pages11
JournalHuman Brain Mapping
Volume38
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017
Externally publishedYes

Keywords

  • brain network
  • depression
  • diffusion tractography
  • functional MRI
  • Huntington's disease

Cite this

McColgan, P., Razi, A., Gregory, S., Seunarine, K. K., Durr, A., A.C. Roos, R., Leavitt, B. R., Scahill, R. I., Clark, C. A., Langbehn, D. R., Rees, G., Tabrizi, S. J., & Track On-HD Investigators (2017). Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease. Human Brain Mapping, 38(6), 2819-2829. https://doi.org/10.1002/hbm.23527