STRUBBELIG defines a receptor kinase-mediated signaling pathway regulating organ development in Arabidopsis

David Chevalier, Martine Batoux, Lynette Fulton, Karen Pfister, Ram Yadav, Maja Schellenberg, Kay Schneitz

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Abstract

An open question remains as to what coordinates cell behavior during organogenesis, permitting organs to reach their appropriate size and shape. The Arabidopsis gene STRUBBELIG (SUB) defines a receptor-mediated signaling pathway in plants. SUB encodes a putative leucine-rich repeat transmembrane receptor-like kinase. The mutant sub phenotype suggests that SUB affects the formation and shape of several organs by influencing cell morphogenesis, the orientation of the division plane, and cell proliferation. Mutational analysis suggests that the kinase domain is important for SUB function. Biochemical assays using bacterially expressed fusion proteins indicate that the SUB kinase domain lacks enzymatic phosphotransfer activity. Furthermore, transgenes encoding WT and different mutant variants of SUB were tested for their ability to rescue the mutant sub phenotype. These genetic data also indicate that SUB carries a catalytically inactive kinase domain. The SUB receptor-like kinase may therefore signal in an atypical fashion.
Original languageEnglish
Pages (from-to)9074 - 9079
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number25
DOIs
Publication statusPublished - 2005
Externally publishedYes

Cite this